PMID- 29458450
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Linking)
VI  - 12
IP  - 11
DP  - 2018 Nov
TI  - Transcriptomic and metabolomic responses induced in the livers of growing pigs by 
      a short-term intravenous infusion of sodium butyrate.
PG  - 2318-2326
LID - 10.1017/S1751731118000174 [doi]
AB  - Previous studies showed that butyrate played benefit roles in the health and 
      metabolism of animals. However, little information on the effects of butyrate on 
      the metabolism of piglets at the extraintestinal level is available. The present 
      study investigated transcriptomic and metabolomic responses in the livers of pigs 
      to evaluate the effects of intravenous sodium butyrate (SB) on the body's 
      metabolism at the extraintestinal level. A total of 12 DurocxLandracexLarge White 
      growing barrows (60 days of age) fitted with jugular vein cannula were randomly 
      allocated to either the SB group or the control (CO) group. Pigs in the SB group 
      were intravenously infused with 10 ml SB (200 mmol/l) for 7 days, whereas pigs in 
      the CO group were treated with the same amount of saline. The livers of pigs were 
      collected for gene expression and metabolome analyses. The RNA sequencing 
      (RNA-Seq) analysis showed that the mRNA expression of Acyl-CoA synthetase 
      long-chain family member 1 (ACSL1), carnitine palmitoyltransferase 1A (CPT1A), 
      acetyl-CoA acyltransferase 2 (ACAA2) and phosphoenolpyruvate carboxykinase 1 
      (PCK1) were downregulated (Q<0.05), whereas fatty acid binding protein 1 (FABP1) 
      and cytochrome P450 family 7 subfamily A member 1 (CYP7A1) were upregulated 
      (P<0.05) by SB treatment, indicating a decrease in fatty acid oxidation and 
      gluconeogenesis and an increase in fatty acid transportation and cholesterol 
      metabolism. Gas chromatography-mass spectrometry analysis showed that raffinose 
      was enriched in the SB group compared with the CO group, indicating a decrease in 
      metabolism of galactose. Moreover, SB treatment significantly decreased the 
      concentration of blood cholesterol. The results suggest that a short-term 
      intravenous infusion of SB could modulate hepatic lipid metabolism by decreasing 
      fatty acid oxidation and increasing fatty acid transportation and cholesterol 
      metabolism.
FAU - Ren, E
AU  - Ren E
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
FAU - Chen, X
AU  - Chen X
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
FAU - Yu, S
AU  - Yu S
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
FAU - Xu, J
AU  - Xu J
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
FAU - Su, Y
AU  - Su Y
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
FAU - Zhu, W
AU  - Zhu W
AD  - Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health,College of 
      Animal Science and Technology,Nanjing Agricultural 
      University,Nanjing210095,Jiangsu,China.
LA  - eng
PT  - Journal Article
DEP - 20180220
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
RN  - 107-92-6 (Butyric Acid)
SB  - IM
MH  - Animals
MH  - Butyric Acid/*administration & dosage
MH  - Infusions, Intravenous
MH  - Lipid Metabolism
MH  - Liver/metabolism
MH  - Metabolome/*drug effects
MH  - Metabolomics
MH  - Oxidation-Reduction
MH  - Random Allocation
MH  - Swine/*physiology
MH  - Transcriptome/*drug effects
OTO - NOTNLM
OT  - liver
OT  - metabolomics
OT  - pig
OT  - sodium butyrate
OT  - transcriptomic
EDAT- 2018/02/21 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/02/21 06:00
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
AID - S1751731118000174 [pii]
AID - 10.1017/S1751731118000174 [doi]
PST - ppublish
SO  - Animal. 2018 Nov;12(11):2318-2326. doi: 10.1017/S1751731118000174. Epub 2018 Feb 
      20.