PMID- 29459123
OWN - NLM
STAT- MEDLINE
DCOM- 20180927
LR  - 20190123
IS  - 1875-0834 (Electronic)
IS  - 1760-2734 (Linking)
VI  - 20
IP  - 2
DP  - 2018 Apr
TI  - High-pressure balloon valvuloplasty for severe pulmonary valve stenosis: a 
      prospective observational pilot study in 25 dogs.
PG  - 115-122
LID - S1760-2734(17)30152-2 [pii]
LID - 10.1016/j.jvc.2018.01.001 [doi]
AB  - OBJECTIVES: We aimed to evaluate safety and efficacy of high-pressure balloon 
      valvuloplasty (HPBVP) for treatment of canine severe pulmonary valve stenosis 
      (PS). A secondary aim was to provide pre-procedure predictors of success. 
      ANIMALS: Twenty-five dogs. METHODS: Prospective observational study. Dogs with 
      severe PS (echocardiographically derived trans-pulmonary peak/maximum pressure 
      gradient (EDPG) >/=80 mmHg) were recruited. All dogs underwent echocardiography 
      before and 20-24hrs after HPBVP using a high-pressure balloon with rated burst 
      pressures ranging from 12 to 18 ATM. Procedural success was defined as a 
      post-HPBVP EDPG reduction of >/=50% or reduction into at least the moderate 
      category of PS (50-79 mmHg). Optimal result was defined as a post-procedural EDPG 
      </=30 mmHg. RESULTS: Initial median (IQR) EDPG for all dogs was 96 (88, 127) mmHg 
      with a post-operative median of 48 (36, 65) mmHg. The median EDPG reduction 
      provided by HPBVP was 63% (39, 68); procedural success rate was 92% (23 dogs). 
      Optimal results were achieved in 56% (14 dogs). There were no significant 
      correlations between EDPG reduction and valve morphology (Type A and Type B) or 
      severity of right ventricular hypertrophy. Pulmonary valve annulus diameter was 
      the only echocardiographic variable that was significantly correlated to EDPG 
      reduction (p = 0.02; r = -0.46). No dog experienced any anesthetic or surgical 
      complications, and all patients survived the procedure. CONCLUSIONS: In this 
      cohort of 25 dogs with severe PS, HPBVP was safe and effective. The procedural 
      success rate and high number of optimal results achieved with HPBVP suggest 
      future randomized controlled trials comparing HPBVP to conventional valvuloplasty 
      are warranted.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Belanger, Catherine
AU  - Belanger C
AD  - William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary 
      Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616 
      USA.
FAU - Gunther-Harrington, Catherine T
AU  - Gunther-Harrington CT
AD  - Department of Medicine & Epidemiology, School of Veterinary Medicine, University 
      of California, Davis, One Shields Avenue, Davis, CA 95616 USA.
FAU - Nishimura, Satoko
AU  - Nishimura S
AD  - William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary 
      Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616 
      USA.
FAU - Oldach, Maureen S
AU  - Oldach MS
AD  - William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary 
      Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616 
      USA.
FAU - Fousse, Samantha L
AU  - Fousse SL
AD  - Department of Medicine & Epidemiology, School of Veterinary Medicine, University 
      of California, Davis, One Shields Avenue, Davis, CA 95616 USA.
FAU - Visser, Lance C
AU  - Visser LC
AD  - Department of Medicine & Epidemiology, School of Veterinary Medicine, University 
      of California, Davis, One Shields Avenue, Davis, CA 95616 USA.
FAU - Stern, Joshua A
AU  - Stern JA
AD  - Department of Medicine & Epidemiology, School of Veterinary Medicine, University 
      of California, Davis, One Shields Avenue, Davis, CA 95616 USA. Electronic 
      address: jstern@ucdavis.edu.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180217
PL  - Netherlands
TA  - J Vet Cardiol
JT  - Journal of veterinary cardiology : the official journal of the European Society 
      of Veterinary Cardiology
JID - 101163270
SB  - IM
MH  - Animals
MH  - Balloon Valvuloplasty/methods/*veterinary
MH  - Blood Pressure
MH  - Dog Diseases/congenital/*therapy
MH  - Dogs
MH  - Echocardiography/veterinary
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Pulmonary Valve Stenosis/congenital/therapy/*veterinary
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Balloon dilation
OT  - Congenital heart disease
OT  - Interventional radiology
OT  - Pulmonic stenosis
EDAT- 2018/02/21 06:00
MHDA- 2018/09/28 06:00
CRDT- 2018/02/21 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/11/13 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2018/09/28 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
AID - S1760-2734(17)30152-2 [pii]
AID - 10.1016/j.jvc.2018.01.001 [doi]
PST - ppublish
SO  - J Vet Cardiol. 2018 Apr;20(2):115-122. doi: 10.1016/j.jvc.2018.01.001. Epub 2018 
      Feb 17.