PMID- 29459306
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20190830
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 163
DP  - 2018 May
TI  - Organochlorine concentrations in adipose tissue and survival in postmenopausal, 
      Danish breast cancer patients.
PG  - 237-248
LID - S0013-9351(18)30061-6 [pii]
LID - 10.1016/j.envres.2018.02.003 [doi]
AB  - BACKGROUND: Several studies have investigated an association between 
      organochlorine-concentrations and breast cancer incidence, whereas few have 
      investigated an association with breast cancer mortality. METHODS: We used Cox 
      Proportional Hazards Models to estimate the association between adipose 
      organochlorine-concentrations and mortality after breast cancer in a 
      survivor-cohort of 399 postmenopausal women. During a median follow-up of 16.1 
      years, 177 women died; 119 from breast cancer. RESULTS: There was a general 
      inverse association with PCB-concentration (e.g. SigmaPCBs: Mortality Rate Ratio 
      (MRR) 0.79, 95% confidence interval (CI) (0.64-0.98) per inter-quartile range 
      (IQR)), and for all pesticides, except beta-Hexachlorocyclohexane, which was not 
      associated with mortality (MRR 1.02(0.87-1.18) per IQR), and dieldrin, which was 
      associated with a significantly increased risk of death (MRR 1.22(1.05-1.41) per 
      IQR). We found an interaction with prognostic factors for all PCBs, confining the 
      inverse association to those with adverse prognostic factors. Results for 
      pesticides suggested a similar, but mostly non-significant interaction. Dieldrin 
      diverged from the general picture by being associated with increased mortality 
      across all strata. CONCLUSION: A higher concentration of PCBs and several 
      organochlorine pesticides may be inversely associated with breast cancer 
      mortality among women with adverse prognostic factors. Further studies are 
      required to investigate if this is a causal association. Dieldrin was associated 
      with a higher mortality, regardless of prognostic factors. IMPACT: This is the 
      first study to investigate an association between organochlorine concentrations 
      in adipose tissue and breast cancer mortality. A prominent finding is a strong 
      interaction with prognostic factors. The unexpected direction of association for 
      most organochlorines encourages further studies of the role of individual 
      metabolism of the organochlorines and a potentially stronger effect of the 
      metabolites on mortality.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Roswall, Nina
AU  - Roswall N
AD  - Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen 
      O, Denmark. Electronic address: roswall@cancer.dk.
FAU - Sorensen, Mette
AU  - Sorensen M
AD  - Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen 
      O, Denmark.
FAU - Tjonneland, Anne
AU  - Tjonneland A
AD  - Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen 
      O, Denmark.
FAU - Raaschou-Nielsen, Ole
AU  - Raaschou-Nielsen O
AD  - Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen 
      O, Denmark; Department of Environmental Science, Aarhus University, 
      Frederiksborgvej 399, DK-4000 Roskilde, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180222
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - *Adipose Tissue/chemistry
MH  - Adult
MH  - Aged
MH  - *Breast Neoplasms/mortality
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Middle Aged
MH  - *Polychlorinated Biphenyls/analysis
MH  - Postmenopause
MH  - Risk Factors
OTO - NOTNLM
OT  - Breast cancer
OT  - Organochlorines
OT  - PCB
OT  - Pesticides
OT  - Survival
EDAT- 2018/02/21 06:00
MHDA- 2019/08/31 06:00
CRDT- 2018/02/21 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/02/01 00:00 [revised]
PHST- 2018/02/03 00:00 [accepted]
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
AID - S0013-9351(18)30061-6 [pii]
AID - 10.1016/j.envres.2018.02.003 [doi]
PST - ppublish
SO  - Environ Res. 2018 May;163:237-248. doi: 10.1016/j.envres.2018.02.003. Epub 2018 
      Feb 22.