PMID- 29460634 OWN - NLM STAT- MEDLINE DCOM- 20190603 LR - 20221207 IS - 1535-3907 (Electronic) IS - 1535-3893 (Linking) VI - 17 IP - 4 DP - 2018 Apr 6 TI - Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method. PG - 1575-1585 LID - 10.1021/acs.jproteome.7b00866 [doi] AB - Sulfonylureas are one of the commonly used drugs in type 2 diabetes mellitus (T2DM) but with considerable incidence of monotherapy failure. However, the mechanism of patients' drug response is unclear, and suitability evaluation biomarkers are in urgent need for precision medicine. In this study, a pseudotargeted gas chromatography-mass spectrometry method was employed to investigate the serum metabolic profiling of 66 significant responders and 24 nonsignificant responders at baseline and 16 weeks after gliclazide modified-release (MR) monotherapy. Clinical improvements in blood glucose level and insulin sensitivity were closely associated with the alterations of TCA cycle, ketone body metabolism, lipid oxidation, branched-chain amino acid catabolism, and gut flora metabolism. The different baseline metabolic profiling observed in the two groups implied that patients with lower dyslipidemia level may be more suitable for sulfonylurea therapy. The biomarker panel consisting of HbA(1c), 5,8,11,14,17-eicosapentaenoic acid, methyl 8,11,14-eicosatrienoate, and methyl hexadecanoate shows a very good prediction ability for the suitability of gliclazide treatment, and it may be meaningful in personalized medicine of T2DM patients by sulfonylurea therapy. FAU - Zhou, Yang AU - Zhou Y AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. FAU - Hu, Cheng AU - Hu C AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. AD - Institute for Metabolic Disease , Fengxian Central Hospital Affiliated to Southern Medical University , 6600 Nanfeng Road , Shanghai 201499 , People's Republic of China. FAU - Zhao, Xinjie AU - Zhao X AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. FAU - Luo, Ping AU - Luo P AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. FAU - Lu, Jingyi AU - Lu J AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. FAU - Li, Qing AU - Li Q AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. FAU - Chen, Miao AU - Chen M AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. FAU - Yan, Dandan AU - Yan D AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. FAU - Lu, Xin AU - Lu X AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. FAU - Kong, Hongwei AU - Kong H AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. FAU - Jia, Weiping AU - Jia W AD - Department of Endocrinology and Metabolism , Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus , Shanghai 200233 , China. FAU - Xu, Guowang AU - Xu G AUID- ORCID: 0000-0003-4298-3554 AD - CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. AD - University of Chinese Academy of Sciences , Beijing 100049 , China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180228 PL - United States TA - J Proteome Res JT - Journal of proteome research JID - 101128775 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (Hypoglycemic Agents) RN - 0 (Sulfonylurea Compounds) RN - AAN7QOV9EA (Eicosapentaenoic Acid) RN - G4PX8C4HKV (Gliclazide) SB - IM MH - Adult MH - Biomarkers/analysis MH - Diabetes Mellitus, Type 2/*drug therapy/metabolism MH - Dyslipidemias/drug therapy MH - Eicosapentaenoic Acid/analysis MH - Female MH - Gas Chromatography-Mass Spectrometry MH - Gliclazide/*administration & dosage/pharmacology MH - Glycated Hemoglobin/analysis MH - Humans MH - Hypoglycemic Agents/therapeutic use MH - Male MH - *Metabolomics MH - Middle Aged MH - Serum/*metabolism MH - Sulfonylurea Compounds/therapeutic use OTO - NOTNLM OT - biomarker OT - gas chromatography-mass spectrometry OT - gliclazide modified release OT - metabolomics OT - sulfonylureas OT - type 2 diabetes mellitus EDAT- 2018/02/21 06:00 MHDA- 2019/06/04 06:00 CRDT- 2018/02/21 06:00 PHST- 2018/02/21 06:00 [pubmed] PHST- 2019/06/04 06:00 [medline] PHST- 2018/02/21 06:00 [entrez] AID - 10.1021/acs.jproteome.7b00866 [doi] PST - ppublish SO - J Proteome Res. 2018 Apr 6;17(4):1575-1585. doi: 10.1021/acs.jproteome.7b00866. Epub 2018 Feb 28.