PMID- 29461008
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20210109
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 22
IP  - 5
DP  - 2018 May
TI  - Propofol exposure during early gestation impairs learning and memory in rat 
      offspring by inhibiting the acetylation of histone.
PG  - 2600-2611
LID - 10.1111/jcmm.13524 [doi]
AB  - Propofol is widely used in clinical practice, including non-obstetric surgery in 
      pregnant women. Previously, we found that propofol anaesthesia in maternal rats 
      during the third trimester (E18) caused learning and memory impairment to the 
      offspring rats, but how about the exposure during early pregnancy and the 
      underlying mechanisms? Histone acetylation plays an important role in synaptic 
      plasticity. In this study, propofol was administered to the pregnant rats in the 
      early pregnancy (E7). The learning and memory function of the offspring were 
      tested by Morris water maze (MWM) test on post-natal day 30. Two hours before 
      each MWM trial, histone deacetylase 2 (HDAC2) inhibitor, suberoylanilide 
      hydroxamic acid (SAHA), Senegenin (SEN, traditional Chinese medicine), 
      hippyragranin (HGN) antisense oligonucleotide (HGNA) or vehicle were given to the 
      offspring. The protein levels of HDAC2, acetylated histone 3 (H3) and 4 (H4), 
      cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), 
      N-methyl-D-aspartate receptor (NMDAR) 2 subunit B (NR2B), HGN and synaptophysin 
      in offspring's hippocampus were determined by Western blot or immunofluorescence 
      test. It was discovered that infusion with propofol in maternal rats on E7 leads 
      to impairment of learning and memory in offspring, increased the protein levels 
      of HDAC2 and HGN, decreased the levels of acetylated H3 and H4 and phosphorylated 
      CREB, NR2B and synaptophysin. HDAC2 inhibitor SAHA, Senegenin or HGN antisense 
      oligonucleotide reversed all the changes. Thus, present results indicate exposure 
      to propofol during the early gestation impairs offspring's learning and memory 
      via inhibiting histone acetylation. SAHA, Senegenin and HGN antisense 
      oligonucleotide might have therapeutic value for the adverse effect of propofol.
CI  - (c) 2018 The Authors. Journal of Cellular and Molecular Medicine published by John 
      Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
FAU - Lin, Jiamei
AU  - Lin J
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
AD  - Department of Anesthesiology, the Eastern Hospital of the First Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, China.
FAU - Wang, Shengqiang
AU  - Wang S
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
FAU - Feng, Yunlin
AU  - Feng Y
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
FAU - Zhao, Weihong
AU  - Zhao W
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
FAU - Zhao, Weilu
AU  - Zhao W
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
FAU - Luo, Foquan
AU  - Luo F
AUID- ORCID: 0000-0003-0106-0710
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
FAU - Feng, Namin
AU  - Feng N
AD  - Department of Anesthesiology, the First Affiliated Hospital, Nanchang University, 
      Nanchang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180220
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Histones)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Synaptophysin)
RN  - 06S1QH951L (tenuigenin)
RN  - 58IFB293JI (Vorinostat)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Acetylation/drug effects
MH  - Anesthesia
MH  - Animals
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Down-Regulation/drug effects
MH  - Drugs, Chinese Herbal/pharmacology
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Histone Deacetylase 2/metabolism
MH  - Histones/metabolism
MH  - *Memory/drug effects
MH  - Oligonucleotides, Antisense/pharmacology
MH  - Phosphorylation/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism/*physiopathology
MH  - Propofol/*adverse effects
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synaptophysin/genetics/metabolism
MH  - Vorinostat/pharmacology
PMC - PMC5908131
OTO - NOTNLM
OT  - histone deacetylase
OT  - learning and memory
OT  - pregnancy
OT  - propofol
EDAT- 2018/02/21 06:00
MHDA- 2019/10/24 06:00
PMCR- 2018/05/01
CRDT- 2018/02/21 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - JCMM13524 [pii]
AID - 10.1111/jcmm.13524 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2018 May;22(5):2600-2611. doi: 10.1111/jcmm.13524. Epub 2018 Feb 
      20.