PMID- 29461880
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 37
IP  - 3
DP  - 2018 Mar
TI  - Expression Profiles of Six Atherosclerosis-Associated microRNAs That Cluster in 
      Patients with Hyperhomocysteinemia: A Clinical Study.
PG  - 189-198
LID - 10.1089/dna.2017.3845 [doi]
AB  - The aim of this study is to discuss the hypothesis that expression of plasma 
      atherosclerosis-associated microRNAs (miRNAs) in hyperhomocysteinemia (Hhcy) 
      patients could predict the presence of atherosclerosis from different channels. 
      Six plasma miRNAs (miR-145, miR-155, miR-222, miR-133, miR-217, and miR-30) 
      selected for our study have been confirmed as critical gene regulators involved 
      in atherosclerosis and can be steadily determined in plasma. Expression of the 
      above six plasma circulating miRNAs revealed significant upregulation of two 
      miRNAs (miR-133 and miR-217) and downregulation of three miRNAs (miR-145, 
      miR-155, and miR-222). Six candidate miRNAs showed a significant correlation with 
      homocysteine (Hcy) or lipid parameters. The results of this study indicated that 
      miR-217 was further significantly upregulated in Hhcy + ATH groups than in normal 
      control, Hhcy-, and atherosclerosis-alone (ATH) groups and it showed a 
      significant negative correlation with Hcy and triglycerides. More specifically, 
      miR-217 showed the most specific expression patterns in all patients with 
      atherosclerosis (ATH and Hhcy + ATH groups), which may have been a diagnostic 
      value for Hhcy complicated with atherosclerosis, and predicted the progress of 
      atherosclerosis in Hhcy patients effectively.
FAU - Liu, Kejian
AU  - Liu K
AD  - 1 Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology , Wuhan, China .
AD  - 2 Department of Cardiology, The First Affiliated Hospital, Shihezi University 
      School of Medicine , Shihezi, China .
FAU - Xuekelati, Saiyare
AU  - Xuekelati S
AD  - 3 The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University 
      , Shihezi, China .
FAU - Zhou, Kang
AU  - Zhou K
AD  - 2 Department of Cardiology, The First Affiliated Hospital, Shihezi University 
      School of Medicine , Shihezi, China .
FAU - Yan, Zhitao
AU  - Yan Z
AD  - 2 Department of Cardiology, The First Affiliated Hospital, Shihezi University 
      School of Medicine , Shihezi, China .
FAU - Yang, Xu
AU  - Yang X
AD  - 2 Department of Cardiology, The First Affiliated Hospital, Shihezi University 
      School of Medicine , Shihezi, China .
FAU - Inayat, Azeem
AU  - Inayat A
AD  - 3 The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University 
      , Shihezi, China .
FAU - Wu, Jiangdong
AU  - Wu J
AD  - 3 The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University 
      , Shihezi, China .
FAU - Guo, Xiaomei
AU  - Guo X
AD  - 1 Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology , Wuhan, China .
LA  - eng
PT  - Journal Article
DEP - 20180220
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/*blood/diagnosis
MH  - Biomarkers/blood
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/diagnosis
MH  - Male
MH  - MicroRNAs/*blood/genetics
MH  - Middle Aged
MH  - ROC Curve
MH  - Transcriptome
MH  - Up-Regulation
OTO - NOTNLM
OT  - atherosclerosis
OT  - cluster
OT  - hyperhomocysteinemia
OT  - microRNAs
EDAT- 2018/02/21 06:00
MHDA- 2018/04/18 06:00
CRDT- 2018/02/21 06:00
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
AID - 10.1089/dna.2017.3845 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2018 Mar;37(3):189-198. doi: 10.1089/dna.2017.3845. Epub 2018 Feb 
      20.