PMID- 29462428
OWN - NLM
STAT- MEDLINE
DCOM- 20190104
LR  - 20190104
IS  - 1464-3804 (Electronic)
IS  - 0267-8357 (Linking)
VI  - 33
IP  - 2
DP  - 2018 Apr 13
TI  - Gene mutation and micronucleus assays in gpt delta mice treated with 
      2,2',4,4'-tetrabromodiphenyl ether.
PG  - 153-160
LID - 10.1093/mutage/gey002 [doi]
AB  - Flame retardant polybrominated diphenyl ethers (PBDEs) are a class of persistent 
      organic pollutants (POPs). 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a 
      representative PBDE congener with widespread distribution and relatively high 
      toxicity potential. Although it has been reported that BDE-47 can cause DNA 
      damage in various in vitro systems, few studies have provided in vivo 
      genotoxicity information. The aim of the present study was to investigate the 
      genotoxicity of BDE-47 in mice. Male gpt delta mice were administered BDE-47 by 
      gavage at 0, 0.0015, 1.5, 10 and 30 mg/kg/day, and 6 days per week for six 
      consecutive weeks. Before the first treatment, and at 2.5 and 5 weeks after the 
      first treatment, peripheral blood was collected from tails and the micronucleus 
      assay and the Pig-a gene mutation assay were performed. After the last treatment, 
      the mutant frequencies of the gpt gene in the liver and the germ cells from 
      seminiferous tubules were determined. All these assays failed to produce positive 
      results, suggesting that BDE-47 was neither clastogenic nor mutagenic in both 
      target and non-target tissues in gpt delta mice.
FAU - You, Xinyue
AU  - You X
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Ando, Tomoko
AU  - Ando T
AD  - Division of Genetics and Mutagenesis, National Institute of Health Sciences, 
      Kamiyoga, Setagaya-ku, Tokyo, Japan.
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Xi, Jing
AU  - Xi J
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Cao, Yiyi
AU  - Cao Y
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Liu, Weiying
AU  - Liu W
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Zhang, Xinyu
AU  - Zhang X
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Honma, Masamitsu
AU  - Honma M
AD  - Division of Genetics and Mutagenesis, National Institute of Health Sciences, 
      Kamiyoga, Setagaya-ku, Tokyo, Japan.
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Masumura, Kenichi
AU  - Masumura K
AD  - Division of Genetics and Mutagenesis, National Institute of Health Sciences, 
      Kamiyoga, Setagaya-ku, Tokyo, Japan.
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
FAU - Luan, Yang
AU  - Luan Y
AD  - Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and 
      Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (Environmental Pollutants)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mutagens)
RN  - 0 (phosphatidylinositol glycan-class A protein)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - EC 2.4.2.- (Pentosyltransferases)
RN  - EC 2.4.2.22 (Gpt protein, E coli)
SB  - IM
MH  - Animals
MH  - DNA Damage/drug effects
MH  - Environmental Pollutants/toxicity
MH  - Escherichia coli Proteins/*genetics
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Liver/drug effects
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Micronucleus Tests
MH  - Mutagenicity Tests
MH  - Mutagens/*toxicity
MH  - Mutation
MH  - Pentosyltransferases/*genetics
EDAT- 2018/02/21 06:00
MHDA- 2019/01/05 06:00
CRDT- 2018/02/21 06:00
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2019/01/05 06:00 [medline]
PHST- 2018/02/21 06:00 [entrez]
AID - 4860134 [pii]
AID - 10.1093/mutage/gey002 [doi]
PST - ppublish
SO  - Mutagenesis. 2018 Apr 13;33(2):153-160. doi: 10.1093/mutage/gey002.