PMID- 2946316
OWN - NLM
STAT- MEDLINE
DCOM- 19870109
LR  - 20190704
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 64
IP  - 2
DP  - 1986 Oct
TI  - Fibronectin-mediated inhibition of human platelet activation by crosslinked 
      immunoglobulin G.
PG  - 299-307
AB  - The effect of purified human plasma fibronectin on stimulation of human platelets 
      with crosslinked immunoglobulin G (IgG) was tested by means of aggregometry, 
      14C-serotonin release and fibronectin-to-platelet binding experiments. 
      Incremental additions of fibronectin to gel-filtered platelets (8 X 10(8)/ml) 
      followed by 25 micrograms/ml bisdiazoniumbenzidine (BDB)-crosslinked IgG produced 
      a dose-related inhibition of platelet aggregation and suppression of 
      14C-serotonin release from the platelets. Evidence was obtained that upon 
      stimulation of the platelets with BDB-IgG, fibronectin becomes bound to its 
      receptor and that further platelet activation is inhibited when a sufficient 
      number of receptors is occupied.
FAU - Spycher, M O
AU  - Spycher MO
FAU - Lerch, P G
AU  - Lerch PG
FAU - Nydegger, U E
AU  - Nydegger UE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Benzidines)
RN  - 0 (Fibronectins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Fibronectin)
RN  - 0 (Receptors, Immunologic)
RN  - 333DO1RDJY (Serotonin)
RN  - 5957-03-9 (bis(diazo)benzidine)
SB  - IM
EIN - Br J Haematol 1987 Apr;65(4):508. Sypcher mo [corrected to Spycher MO]
MH  - Benzidines/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fibronectins/*pharmacology
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - In Vitro Techniques
MH  - Platelet Aggregation/*drug effects
MH  - Receptors, Fibronectin
MH  - Receptors, Immunologic/metabolism
MH  - Serotonin/blood
MH  - Time Factors
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1986.tb04123.x [doi]
PST - ppublish
SO  - Br J Haematol. 1986 Oct;64(2):299-307. doi: 10.1111/j.1365-2141.1986.tb04123.x.