PMID- 29463513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 2046-6390 (Print)
IS  - 2046-6390 (Electronic)
IS  - 2046-6390 (Linking)
VI  - 7
IP  - 2
DP  - 2018 Feb 20
TI  - Metabolism of the Pacific oyster, Crassostrea gigas, is influenced by salinity 
      and modulates survival to the Ostreid herpesvirus OsHV-1.
LID - 10.1242/bio.028134 [doi]
LID - bio028134
AB  - The Pacific oyster, Crassostrea gigas, is an osmoconforming bivalve exposed to 
      wide salinity fluctuations. The physiological mechanisms used by oysters to cope 
      with salinity stress are energy demanding and may impair other processes, such as 
      defense against pathogens. This oyster species has been experiencing recurrent 
      mortality events caused by the Ostreid herpesvirus 1 (OsHV-1). The objectives of 
      this study were to investigate the effect of salinity (10, 15, 25 and 35 per thousand) on 
      energetic reserves, key enzyme activities and membrane fatty acids, and to 
      identify the metabolic risk factors related to OsHV-1-induced mortality of 
      oysters. Acclimation to low salinity led to increased water content, protein 
      level, and energetic reserves (carbohydrates and triglycerides) of oysters. The 
      latter was consistent with lower activity of hexokinase, the first enzyme 
      involved in glycolysis, up-regulation of AMP-activated protein kinase, a major 
      regulator of cellular energy metabolism, and lower activity of catalase, an 
      antioxidant enzyme involved in management of reactive oxygen species. Acclimation 
      to salinity also involved a major remodeling of membrane fatty acids. 
      Particularly, 20:4n-6 decreased linearly with decreasing salinity, likely 
      reflecting its mobilization for prostaglandin synthesis in oysters. The survival 
      of oysters exposed to OsHV-1 varied from 43% to 96% according to salinity ( 
      Fuhrmann et al., 2016). Risk analyses showed that activity of superoxide 
      dismutase and levels of proteins, carbohydrates, and triglycerides were 
      associated with a reduced risk of death. Therefore, animals with a higher 
      antioxidant activity and a better physiological condition seemed less susceptible 
      to OsHV-1.
CI  - (c) 2018. Published by The Company of Biologists Ltd.
FAU - Fuhrmann, Marine
AU  - Fuhrmann M
AUID- ORCID: 0000-0002-4828-9275
AD  - Ifremer/LEMAR UMR 6539 (UBO/CNRS/IRD/Ifremer), Technopole de Brest-Iroise, 29280 
      Plouzane, France marine.fuhrmann@gmail.com.
FAU - Delisle, Lizenn
AU  - Delisle L
AD  - Ifremer/LEMAR UMR 6539 (UBO/CNRS/IRD/Ifremer), Technopole de Brest-Iroise, 29280 
      Plouzane, France.
FAU - Petton, Bruno
AU  - Petton B
AD  - Ifremer/LEMAR UMR 6539 (UBO/CNRS/IRD/Ifremer), Presqu'ile du vivier, 29840 
      Argenton, France.
FAU - Corporeau, Charlotte
AU  - Corporeau C
AD  - Ifremer/LEMAR UMR 6539 (UBO/CNRS/IRD/Ifremer), Technopole de Brest-Iroise, 29280 
      Plouzane, France.
FAU - Pernet, Fabrice
AU  - Pernet F
AD  - Ifremer/LEMAR UMR 6539 (UBO/CNRS/IRD/Ifremer), Technopole de Brest-Iroise, 29280 
      Plouzane, France.
LA  - eng
PT  - Journal Article
DEP - 20180220
PL  - England
TA  - Biol Open
JT  - Biology open
JID - 101578018
PMC - PMC5861354
OTO - NOTNLM
OT  - Bivalve
OT  - Disease
OT  - Environment
OT  - Metabolism
OT  - Mortality risk
OT  - Salinity
COIS- Competing interestsThe authors declare no competing or financial interests.
EDAT- 2018/02/22 06:00
MHDA- 2018/02/22 06:01
PMCR- 2018/02/15
CRDT- 2018/02/22 06:00
PHST- 2018/02/22 06:00 [entrez]
PHST- 2018/02/22 06:00 [pubmed]
PHST- 2018/02/22 06:01 [medline]
PHST- 2018/02/15 00:00 [pmc-release]
AID - bio.028134 [pii]
AID - BIO028134 [pii]
AID - 10.1242/bio.028134 [doi]
PST - epublish
SO  - Biol Open. 2018 Feb 20;7(2):bio028134. doi: 10.1242/bio.028134.