PMID- 29464125
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20231105
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2017
DP  - 2017
TI  - Botanicals as Modulators of Neuroplasticity: Focus on BDNF.
PG  - 5965371
LID - 10.1155/2017/5965371 [doi]
LID - 5965371
AB  - The involvement of brain-derived neurotrophic factor (BDNF) in different central 
      nervous system (CNS) diseases suggests that this neurotrophin may represent an 
      interesting and reliable therapeutic target. Accordingly, the search for new 
      compounds, also from natural sources, able to modulate BDNF has been increasingly 
      explored. The present review considers the literature on the effects of 
      botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, 
      Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia 
      sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea 
      europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia 
      miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla 
      frutescens (L.) Britton. The effect of the active principles responsible for the 
      efficacy of the extracts is reviewed and discussed as well. The high number of 
      articles published (more than one hundred manuscripts for 14 botanicals) supports 
      the growing interest in the use of natural products as BDNF modulators. The 
      studies reported strengthen the hypothesis that botanicals may be considered 
      useful modulators of BDNF in CNS diseases, without high side effects. Further 
      clinical studies are mandatory to confirm botanicals as preventive agents or as 
      useful adjuvant to the pharmacological treatment.
FAU - Sangiovanni, Enrico
AU  - Sangiovanni E
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Brivio, Paola
AU  - Brivio P
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Dell'Agli, Mario
AU  - Dell'Agli M
AUID- ORCID: 0000-0001-5378-402X
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Calabrese, Francesca
AU  - Calabrese F
AUID- ORCID: 0000-0001-7946-2424
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171231
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Humans
MH  - *Neuronal Plasticity
MH  - Neurons/*drug effects/physiology
MH  - Plant Extracts/*pharmacology
PMC - PMC5804326
EDAT- 2018/02/22 06:00
MHDA- 2018/09/05 06:00
PMCR- 2017/12/31
CRDT- 2018/02/22 06:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/11/09 00:00 [revised]
PHST- 2017/12/02 00:00 [accepted]
PHST- 2018/02/22 06:00 [entrez]
PHST- 2018/02/22 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2017/12/31 00:00 [pmc-release]
AID - 10.1155/2017/5965371 [doi]
PST - ppublish
SO  - Neural Plast. 2017;2017:5965371. doi: 10.1155/2017/5965371. Epub 2017 Dec 31.