PMID- 29464752
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20200403
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Print)
IS  - 0733-2467 (Linking)
VI  - 37
IP  - 5
DP  - 2018 Jun
TI  - Voluntary wheel running attenuates urinary bladder hypersensitivity and 
      dysfunction following neonatal maternal separation in female mice.
PG  - 1623-1632
LID - 10.1002/nau.23530 [doi]
AB  - AIMS: Patients with interstitial cystitis/painful bladder syndrome (IC/PBS) 
      commonly suffer from widespread pain and mood disorder, which has been attributed 
      to improper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. 
      Voluntary exercise has been shown to improve HPA axis function, therefore we are 
      determining whether voluntary wheel running can attenuate urological pain and 
      dysfunction following neonatal maternal separation (NMS) in female mice. METHODS: 
      Mice underwent NMS for 3 h/day from postnatal Day 1-21, were caged with free 
      access to running wheels at 4 weeks of age, and assessed 4 weeks later for 
      bladder sensitivity, micturition, reward behavior, mast cell degranulation, and 
      HPA axis-related in vitro analysis. RESULTS: Increased bladder sensitivity, void 
      frequency, and mast cell degranulation was observed in adult sedentary (-Sed) NMS 
      mice, compared to naive-Sed controls. Sucrose preference was increased in NMS-Sed 
      mice and corticotropin-releasing factor receptor 1 (CRF(1) ) and glucocorticoid 
      receptor mRNA levels were significantly reduced in the hippocampus. Exercise 
      normalized bladder sensitivity, micturition output, and increased brain-derived 
      neurotrophic factor (BDNF) mRNA levels in the hippocampus of NMS mice. Mast cell 
      degranulation was also normalized in NMS bladders following exercise. 
      CONCLUSIONS: Voluntary exercise normalized behavioral outcomes resulting from NMS 
      in female mice, increased hippocampal BDNF mRNA levels, and decreased mast cell 
      degranulation in the bladder. Together these results provide novel insight into 
      the efficacy of voluntary exercise to attenuate comorbid outcomes resulting from 
      exposure to early life stress.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Pierce, Angela N
AU  - Pierce AN
AD  - Department of Anatomy and Cell Biology, School of Medicine, University of Kansas 
      Medical Center, Kansas City, Kansas.
FAU - Eller-Smith, Olivia C
AU  - Eller-Smith OC
AD  - Department of Anatomy and Cell Biology, School of Medicine, University of Kansas 
      Medical Center, Kansas City, Kansas.
FAU - Christianson, Julie A
AU  - Christianson JA
AUID- ORCID: 0000-0003-4117-5192
AD  - Department of Anatomy and Cell Biology, School of Medicine, University of Kansas 
      Medical Center, Kansas City, Kansas.
LA  - eng
GR  - P30 GM122731/GM/NIGMS NIH HHS/United States
GR  - P20 GM104936/GM/NIGMS NIH HHS/United States
GR  - T32 HD057850/HD/NICHD NIH HHS/United States
GR  - P20 GM103418/GM/NIGMS NIH HHS/United States
GR  - R01 DK103872/DK/NIDDK NIH HHS/United States
GR  - U54 HD090216/HD/NICHD NIH HHS/United States
GR  - R01 DK099611/DK/NIDDK NIH HHS/United States
GR  - P30 HD002528/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180221
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Female
MH  - Hippocampus/metabolism
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - *Maternal Deprivation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/*physiology
MH  - Pituitary-Adrenal System/physiopathology
MH  - Running
MH  - Stress, Psychological/metabolism/*physiopathology
MH  - Urinary Bladder/*physiopathology
MH  - Urination/*physiology
PMC - PMC6103918
MID - NIHMS951676
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - corticotropin-releasing hormone
OT  - mast cell
OT  - pain
OT  - pituitary-adrenal system
EDAT- 2018/02/22 06:00
MHDA- 2019/10/01 06:00
PMCR- 2019/06/01
CRDT- 2018/02/22 06:00
PHST- 2017/11/14 00:00 [received]
PHST- 2018/01/28 00:00 [accepted]
PHST- 2018/02/22 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2018/02/22 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.1002/nau.23530 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2018 Jun;37(5):1623-1632. doi: 10.1002/nau.23530. Epub 2018 Feb 
      21.