PMID- 2946652
OWN - NLM
STAT- MEDLINE
DCOM- 19870116
LR  - 20221207
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 61
IP  - 5
DP  - 1986 Nov
TI  - Skeletal muscle characteristics in sedentary black and Caucasian males.
PG  - 1758-61
AB  - Twenty-three male Black African and 23 male Caucasian subjects, ascertained as 
      sedentary, participated in this study designed to determine whether there were 
      differences in skeletal muscle histochemical and biochemical characteristics 
      between racial groups. Muscle fiber type proportions (I, IIa, and IIb), fiber 
      areas and activities of several enzyme markers of different energy metabolic 
      pathways were determined from a biopsy of the vastus lateralis. Results indicated 
      that Caucasians had a higher percent type I (8%, P less than 0.01) and a lower 
      percent type IIa (6.7%, P less than 0.05) fiber proportions than Africans. No 
      significant differences were observed between the two racial groups in the type 
      IIb fiber proportion or in the three fiber type areas. Enzymes catalyzing 
      reactions in phosphagenic [creatine kinase (CK)] and glycolytic [hexokinase (HK), 
      phosphofructokinase (PFK), and lactate dehydrogenase (LDH)] metabolic pathways 
      had significantly higher activities (about 30-40%) in the Black African group 
      than in the Caucasian group (P less than 0.01). No significant difference was 
      noted in the activities of oxidative enzymes [malate dehydrogenase (MDH), 
      oxoglutarate dehydrogenase (OGDH), and 3-hydroxyacyl-CoA dehydrogenase (HADH)]. 
      Consequently, the PFK/OGDH ratio was significantly elevated in Africans (P less 
      than 0.05). The racial differences observed between Africans and Caucasians in 
      fiber type proportion and enzyme activities of the phosphagenic and glycolytic 
      metabolic pathways may well result from inherited variation. These data suggest 
      that sedentary male Black individuals are, in terms of skeletal muscle 
      characteristics, well endowed for sport events of short duration.
FAU - Ama, P F
AU  - Ama PF
FAU - Simoneau, J A
AU  - Simoneau JA
FAU - Boulay, M R
AU  - Boulay MR
FAU - Serresse, O
AU  - Serresse O
FAU - Theriault, G
AU  - Theriault G
FAU - Bouchard, C
AU  - Bouchard C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.2.4.2 (Ketoglutarate Dehydrogenase Complex)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - *Black People
MH  - Creatine Kinase/metabolism
MH  - Hexokinase/metabolism
MH  - Humans
MH  - Ketoglutarate Dehydrogenase Complex/metabolism
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Male
MH  - Muscles/*anatomy & histology/enzymology
MH  - Phosphofructokinase-1/metabolism
MH  - *Physical Fitness
MH  - *White People
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1152/jappl.1986.61.5.1758 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1986 Nov;61(5):1758-61. doi: 10.1152/jappl.1986.61.5.1758.