PMID- 29467354
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 4
DP  - 2018 Mar 23
TI  - High Signal Intensity on T2-Weighted Cardiovascular Magnetic Resonance Imaging 
      Predicts Life-Threatening Arrhythmic Events in Hypertrophic Cardiomyopathy 
      Patients.
PG  - 1062-1069
LID - 10.1253/circj.CJ-17-1235 [doi]
AB  - BACKGROUND: The prognostic value of high signal intensity on T2-weighted 
      cardiovascular magnetic resonance imaging (T2 high signal) in hypertrophic 
      cardiomyopathy (HCM) patients in a single-center cohort was 
      investigated.Methods and Results:A total of 237 HCM patients (median age, 62 
      years; 143 male) underwent T2-weighted, cine and late gadolinium enhancement 
      (LGE) imaging, and were followed (median duration, 3.4 years) for 
      life-threatening arrhythmic events. The clinical and magnetic resonance imaging 
      characteristics were extracted, and predictors of life-threatening arrhythmic 
      events were assessed on multivariate analysis. LGE was present in 180 patients 
      (75.9%). Median LGE score was 3 in a left ventricle 17-segment model. T2 high 
      signal was present in 49 patients (20.7%). The annual events rate was 
      significantly higher in patients with extensive LGE (score >/=4) than in those 
      without (3.0%/year vs. 0.5%/year, P=0.011). On multivariate analysis, extensive 
      LGE (hazard ratio, 5.650; 95% CI: 1.263-25.000, P=0.024) as an independent 
      predictor for life-threatening arrhythmic events. In patients with extensive LGE, 
      the annual events rate was significantly higher in patients with T2 high signal 
      than in those without (5.8%/year vs. 0.9%/year, P=0.008). CONCLUSIONS: Extensive 
      LGE was an independent predictor of life-threatening arrhythmic events in HCM 
      patients. Furthermore, T2 high signal is useful for the risk stratification of 
      serious arrhythmic events in patients with extensive LGE.
FAU - Hen, Yasuki
AU  - Hen Y
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Takara, Ayako
AU  - Takara A
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Iguchi, Nobuo
AU  - Iguchi N
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Utanohara, Yuko
AU  - Utanohara Y
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Teraoka, Kunihiko
AU  - Teraoka K
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Takada, Kaori
AU  - Takada K
AD  - Department of Radiology, Sakakibara Heart Institute.
FAU - Machida, Haruhiko
AU  - Machida H
AD  - Department of Radiology, Kyorin University School of Medicine.
FAU - Takamisawa, Itaru
AU  - Takamisawa I
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Takayama, Morimasa
AU  - Takayama M
AD  - Department of Cardiology, Sakakibara Heart Institute.
FAU - Yoshikawa, Tsutomu
AU  - Yoshikawa T
AD  - Department of Cardiology, Sakakibara Heart Institute.
LA  - eng
PT  - Journal Article
DEP - 20180221
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
MH  - Aged
MH  - Arrhythmias, Cardiac/*diagnosis
MH  - Cardiomyopathy, Hypertrophic/diagnosis/*diagnostic imaging
MH  - Cohort Studies
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment/methods
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Life-threatening arrhythmic event
OT  - T2-weighted imaging
EDAT- 2018/02/23 06:00
MHDA- 2019/08/14 06:00
CRDT- 2018/02/23 06:00
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - 10.1253/circj.CJ-17-1235 [doi]
PST - ppublish
SO  - Circ J. 2018 Mar 23;82(4):1062-1069. doi: 10.1253/circj.CJ-17-1235. Epub 2018 Feb 
      21.