PMID- 29467613
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240313
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 12
DP  - 2018
TI  - Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.
PG  - 52
LID - 10.3389/fnins.2018.00052 [doi]
LID - 52
AB  - Exercise is known to have numerous neuroprotective and cognitive benefits, 
      especially pertaining to memory and learning related processes. One potential 
      link connecting them is exercise-mediated hippocampal neurogenesis, in which new 
      neurons are generated and incorporated into hippocampal circuits. The present 
      review synthesizes the extant literature detailing the relationship between 
      exercise and hippocampal neurogenesis, and identifies a key molecule mediating 
      this process, brain-derived neurotrophic factor (BDNF). As a member of the 
      neurotrophin family, BDNF regulates many of the processes within neurogenesis, 
      such as differentiation and survival. Although much more is known about the 
      direct role that exercise and BDNF have on hippocampal neurogenesis in rodents, 
      their corresponding cognitive benefits in humans will also be discussed. 
      Specifically, what is known about exercise-mediated hippocampal neurogenesis will 
      be presented as it relates to BDNF to highlight the critical role that it plays. 
      Due to the inaccessibility of the human brain, much less is known about the role 
      BDNF plays in human hippocampal neurogenesis. Limitations and future areas of 
      research with regards to human neurogenesis will thus be discussed, including 
      indirect measures of neurogenesis and single nucleotide polymorphisms within the 
      BDNF gene.
FAU - Liu, Patrick Z
AU  - Liu PZ
AD  - Department of Psychology, Northwestern University, Evanston, IL, United States.
FAU - Nusslock, Robin
AU  - Nusslock R
AD  - Department of Psychology, Northwestern University, Evanston, IL, United States.
LA  - eng
GR  - R01 MH077908/MH/NIMH NIH HHS/United States
GR  - R01 MH100117/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180207
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC5808288
OTO - NOTNLM
OT  - TrkB
OT  - dentate gyrus
OT  - neuroprotective
OT  - neurotrophin
OT  - subgranular zone
EDAT- 2018/02/23 06:00
MHDA- 2018/02/23 06:01
PMCR- 2018/01/01
CRDT- 2018/02/23 06:00
PHST- 2017/11/19 00:00 [received]
PHST- 2018/01/23 00:00 [accepted]
PHST- 2018/02/23 06:00 [entrez]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/02/23 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2018.00052 [doi]
PST - epublish
SO  - Front Neurosci. 2018 Feb 7;12:52. doi: 10.3389/fnins.2018.00052. eCollection 
      2018.