PMID- 29468225
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2451-9936 (Electronic)
IS  - 2451-9936 (Linking)
VI  - 9
DP  - 2018 Mar
TI  - Multimodal imaging of macular subretinal deposits following intravitreal 
      ocriplasmin injection.
PG  - 80-84
LID - 10.1016/j.ajoc.2018.01.016 [doi]
AB  - PURPOSE: Ocriplasmin is effective in closing macular holes due to vitreomacular 
      traction. We present a case of macular subretinal material deposition observed 
      with spectral-domain optical coherence tomography (SD-OCT) and multimodal 
      imaging, following successful closure of a macular hole following intravitreal 
      ocriplasmin injection. OBSERVATIONS: An 81-year-old male presented with decreased 
      vision in the left eye due to a full-thickness macular hole secondary to 
      vitreomacular traction. Ocriplasmin (Jetrea) was injected into the vitreous and 
      hole closure was observed after one week. Macular subretinal material deposition 
      developed along the outer surface of the resultant serous detachment on OCT one 
      week post-injection. Fluorescein angiography demonstrated no expanding 
      hyperfluorescence due to retinal or choroidal leak, or staining of the lesion. 
      The material was mildly autofluorescent. The macular subretinal material complex 
      spontaneously decreased with no significant effect on vision over 60 weeks. 
      CONCLUSIONS AND IMPORTANCE: Macular subretinal material deposition has not 
      previously been reported following intravitreal ocriplasmin injection. This 
      material is likely composed of photoreceptor outer segments. It is important to 
      recognize that macular subretinal deposits can occur following intravitreal 
      ocriplasmin injection as it may cause diagnostic confusion and potentially 
      influence the visual and anatomical outcomes following successful hole closure.
FAU - Chow, Nicholas
AU  - Chow N
AD  - Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, 
      Australia.
AD  - Sydney Institute of Vision Science, (Lvl 7) 187 Macquarie St, Sydney, NSW, 
      Australia.
FAU - Hong, Thomas
AU  - Hong T
AD  - Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, 
      Australia.
AD  - Sydney Institute of Vision Science, (Lvl 7) 187 Macquarie St, Sydney, NSW, 
      Australia.
FAU - Chang, Andrew
AU  - Chang A
AD  - Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW, 
      Australia.
AD  - Sydney Institute of Vision Science, (Lvl 7) 187 Macquarie St, Sydney, NSW, 
      Australia.
AD  - Save Sight Institute, 8 Macquarie St, Sydney, NSW, Australia.
LA  - eng
PT  - Case Reports
DEP - 20180110
PL  - United States
TA  - Am J Ophthalmol Case Rep
JT  - American journal of ophthalmology case reports
JID - 101679941
PMC - PMC5786887
OTO - NOTNLM
OT  - Jetrea
OT  - Macular integrity assessment
OT  - Macular subretinal material
OT  - Ocriplasmin
OT  - Optical coherence tomography
OT  - Vitreomacular traction
EDAT- 2018/02/23 06:00
MHDA- 2018/02/23 06:01
PMCR- 2018/01/10
CRDT- 2018/02/23 06:00
PHST- 2017/05/20 00:00 [received]
PHST- 2018/01/04 00:00 [revised]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/02/23 06:00 [entrez]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/02/23 06:01 [medline]
PHST- 2018/01/10 00:00 [pmc-release]
AID - S2451-9936(17)30152-4 [pii]
AID - 10.1016/j.ajoc.2018.01.016 [doi]
PST - epublish
SO  - Am J Ophthalmol Case Rep. 2018 Jan 10;9:80-84. doi: 10.1016/j.ajoc.2018.01.016. 
      eCollection 2018 Mar.