PMID- 29468477
OWN - NLM
STAT- MEDLINE
DCOM- 20190205
LR  - 20190215
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 33
IP  - 3
DP  - 2018 Jun
TI  - Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a 
      rat chronic unpredictable mild stress model by involving monoamines and BDNF.
PG  - 885-892
LID - 10.1007/s11011-018-0202-x [doi]
AB  - The dried roots of Rehmannia glutinosa Libosch. (Scrophulariaceae) are of both 
      medicinal and nutritional importance. Our previous study has found that the 80% 
      ethanol extract of R. glutinosa (RGEE) produced antidepressant-like activities in 
      mouse behavioral despair depression models. However, its mechanisms are still 
      unclear. The present study aimed to observe the antidepressant-like mechanisms of 
      RGEE on a rat chronic unpredictable mild stress (CUMS) model by involving 
      monoaminergic neurotransmitters and brain-derived neurotrophic factor (BDNF). 
      CUMS-stressed rats were orally given RGEE daily (150, 300, and 600 mg/kg) or 
      fluoxetine hydrochloride (FH) for 3 weeks after starting the CUMS procedure. 
      Sucrose preference test was carried out to observe depression-like behavior, and 
      serum and brain tissues were used for neurochemical and fluorescent quantitative 
      reverse transcription PCR analysis. Results demonstrated that CUMS induced 
      depression-like behavior, whereas RGEE and FH administration inhibited this 
      symptom. Furthermore, CUMS caused excessively elevated levels of serum 
      corticosterone (CORT), an index of hypothalamic-pituitary-adrenal (HPA) axis 
      hyperactivity, in a manner attenuated by RGEE and FH administration. RGEE 
      administration also further elevated monoamine neurotransmitters and BDNF levels, 
      up-regulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB) 
      in hippocampus of rats suffering CUMS. Together, our findings suggest that RGEE 
      can improve CUMS-evoked depression-like behavior, and indicate its mechanisms may 
      partially be associated with restoring HPA axis dysfunctions, enhancing 
      monoamineergic nervous systems, and up-regulating BDNF and TrkB expression.
FAU - Wang, Jun-Ming
AU  - Wang JM
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China. mjw98_2010@163.com.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Traditional 
      Chinese Medicine, Zhengzhou, 450046, China. mjw98_2010@163.com.
FAU - Pei, Li-Xin
AU  - Pei LX
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China.
FAU - Zhang, Yue-Yue
AU  - Zhang YY
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China.
FAU - Cheng, Yong-Xian
AU  - Cheng YX
AD  - Health Science Center, Shenzhen University, Shenzhen, 518060, China.
FAU - Niu, Chun-Ling
AU  - Niu CL
AD  - College of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou, 
      450046, China.
FAU - Cui, Ying
AU  - Cui Y
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Traditional 
      Chinese Medicine, Zhengzhou, 450046, China.
FAU - Feng, Wei-Sheng
AU  - Feng WS
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China. fwsh@hactcm.edu.cn.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Traditional 
      Chinese Medicine, Zhengzhou, 450046, China. fwsh@hactcm.edu.cn.
FAU - Wang, Gui-Fang
AU  - Wang GF
AD  - College of Pharmacy, Henan University of Chinese Medicine, East Jinshui Road & 
      Boxue road, Zhengzhou, 450046, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180222
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 3K9958V90M (Ethanol)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Depressive Disorder/drug therapy
MH  - Disease Models, Animal
MH  - Ethanol/pharmacology
MH  - Hypothalamo-Hypophyseal System/*drug effects
MH  - Male
MH  - Pituitary-Adrenal System/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Rehmannia
OTO - NOTNLM
OT  - Antidepressant
OT  - BDNF
OT  - Chronic unpredictable mild stress
OT  - Monoamineergic nervous system
OT  - Rehmannia glutinosa
EDAT- 2018/02/23 06:00
MHDA- 2019/02/06 06:00
CRDT- 2018/02/23 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2018/02/15 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2019/02/06 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - 10.1007/s11011-018-0202-x [pii]
AID - 10.1007/s11011-018-0202-x [doi]
PST - ppublish
SO  - Metab Brain Dis. 2018 Jun;33(3):885-892. doi: 10.1007/s11011-018-0202-x. Epub 
      2018 Feb 22.