PMID- 29469186
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181001
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 48
IP  - 5
DP  - 2018 May
TI  - Serum brain-derived neurotrophic factor in children with coeliac disease.
PG  - e12916
LID - 10.1111/eci.12916 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has a 
      protective role in the nervous system and is involved in neural plasticity. It is 
      abundant in the central nervous system, but is also expressed in the 
      gastrointestinal tract. Coeliac disease (CD), characterised by intestinal 
      inflammation, has some comorbidity with neurologic and mental disorders. The aim 
      of this study was to evaluate circulating BDNF concentrations in patients with CD 
      at diagnosis or on a gluten-free diet (GFD) for longer than 1 year and in healthy 
      controls (HC). MATERIALS AND METHODS: Fifty newly diagnosed patients with CD 
      (aged 8.6 +/- 3.7 years, 64.0% females), thirty-nine patients on GFD for longer 
      than 1 year (aged 10.4 +/- 3.4 years, 71.8% females) and 36 HC (aged 8 +/- 1.7 years, 
      33.3% females) were included in the study. Along with anthropometric evaluation 
      and standard blood chemistry, serum BDNF levels were measured by a specific 
      immunoenzymatic assay. RESULTS: Patients at diagnosis and on GFD had 
      significantly higher BDNF levels (26 110 +/- 8204 and 28 860 +/- 7992 pg/mL), 
      respectively, than HC (19 630 +/- 8093 pg/mL, P < .001 for both CD groups). 
      Patients on GFD had significantly higher BDNF levels than those at diagnosis (P = 
      .02). CONCLUSIONS: Serum BDNF concentrations were higher in patients with CD than 
      in HC, regardless of their status of gluten consumption. This could be attributed 
      either to a potential protective response to the inflammation of the intestine or 
      to chronic stress.
CI  - (c) 2018 Stichting European Society for Clinical Investigation Journal Foundation.
FAU - Margoni, Daphne
AU  - Margoni D
AUID- ORCID: 0000-0002-1055-7852
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
FAU - Michalakakou, Kelly
AU  - Michalakakou K
AD  - Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, 
      Greece.
FAU - Angeli, Eleni
AU  - Angeli E
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
FAU - Pervanidou, Panagiota
AU  - Pervanidou P
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
FAU - Kanaka-Gantenbein, Christina
AU  - Kanaka-Gantenbein C
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
FAU - Chrousos, George
AU  - Chrousos G
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
FAU - Papassotiriou, Ioannis
AU  - Papassotiriou I
AUID- ORCID: 0000-0002-2126-3251
AD  - Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, 
      Greece.
FAU - Roma, Eleftheria
AU  - Roma E
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20180307
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Age of Onset
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Celiac Disease/*blood/diet therapy
MH  - Child
MH  - Diet, Gluten-Free
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Medication Adherence
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - children
OT  - coeliac disease
OT  - gluten-free diet
OT  - gut inflammation
OT  - stress
EDAT- 2018/02/23 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/02/23 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2018/02/18 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - 10.1111/eci.12916 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2018 May;48(5):e12916. doi: 10.1111/eci.12916. Epub 2018 Mar 
      7.