PMID- 29469765
OWN - NLM
STAT- MEDLINE
DCOM- 20180619
LR  - 20220409
IS  - 1087-2108 (Electronic)
IS  - 1087-2108 (Linking)
VI  - 24
IP  - 1
DP  - 2018 Jan 15
TI  - Nivolumab reactivation of hypertrophic lichen planus, a case report and review of 
      published literature.
LID - 13030/qt4xf465w6 [pii]
AB  - We report a case of nivolumab-induced lichen planus (LP) reactivation that was 
      previously in remission following chemotherapy for non-smallcelllung cancer 
      (NSCLC). Chemotherapy-induced immunosuppression allowed for complete resolution 
      of the patient's pre-existing LP, a T-cell mediatedautoimmune process. When the 
      patient was switched to nivolumab immunotherapy owing to progression of NSCLC, 
      PD-1 inhibition led to an overwhelming T-cell response that seemed to have 
      provoked a severe LPreactivation. Although lichenoid reactions have been reported 
      with nivolumab, to our knowledge, this is the first reported case of nivolumab 
      monotherapycausing LP reactivation in a patient with a strong personal and family 
      history of the disease that was previously in remission after chemotherapy.
FAU - Maarouf, Melody
AU  - Maarouf M
AD  - College of Medicine, University of Arizona, Tucson, Arizona.
FAU - Alexander, Christina
AU  - Alexander C
FAU - Shi, Vivian Y
AU  - Shi VY
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20180115
PL  - United States
TA  - Dermatol Online J
JT  - Dermatology online journal
JID - 9610776
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 31YO63LBSN (Nivolumab)
SB  - IM
MH  - Antibodies, Monoclonal/*adverse effects
MH  - Antineoplastic Agents/*adverse effects
MH  - Carcinoma, Non-Small-Cell Lung/drug therapy
MH  - Humans
MH  - Lichen Planus/*etiology/pathology
MH  - Lung Neoplasms/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Nivolumab
MH  - Programmed Cell Death 1 Receptor/*antagonists & inhibitors
MH  - Recurrence
MH  - Skin/pathology
EDAT- 2018/02/23 06:00
MHDA- 2018/06/21 06:00
CRDT- 2018/02/23 06:00
PHST- 2018/02/13 00:00 [received]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/02/23 06:00 [entrez]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
AID - 13030/qt4xf465w6 [pii]
PST - epublish
SO  - Dermatol Online J. 2018 Jan 15;24(1):13030/qt4xf465w6.