PMID- 29471131
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20190423
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 106
DP  - 2018 Jun
TI  - Aerobic and strength training induce changes in oxidative stress parameters and 
      elicit modifications of various cellular components in skeletal muscle of aged 
      rats.
PG  - 21-27
LID - S0531-5565(18)30033-0 [pii]
LID - 10.1016/j.exger.2018.02.014 [doi]
AB  - Skeletal muscle aging is associated with loss of mass, function, and strength-a 
      condition known as sarcopenia. It has been reported that sarcopenia can be 
      attenuated by physical exercise. Therefore, we investigated whether 2 different 
      physical exercise protocols could modulate and induce changes in oxidative and 
      inflammatory parameters, as well as in BDNF and DNA repair enzyme levels in 
      skeletal muscle tissue of aged rats. Aging Wistar rats performed treadmill or 
      strength training for 50 min 3 to 4 times a week for 8 weeks. Strength training 
      decreased 2',7'-dichlorofluorescein (DCFH) oxidation (P = 0.0062); however, 
      nitric oxide, protein deglycase DJ-1, and tumor necrosis factor alpha (TNF-alpha) 
      levels increased after aerobic training (P = 0.04, P = 0.027 and P = 0.009, 
      respectively). Both exercise protocols increased superoxide dismutase (SOD) and 
      catalase (CAT) activity (P = 0.0017 and P = 0.0326) whereas the activity of 
      glutathione (GSH) (P = 0.0001) was decreased. Brain-derived neurotropic factor 
      (BDNF) levels were not affected by exercise, but 8-oxoguanine glycosylase (OGG1) 
      decreased after strength training (P = 0.0007). In conclusion, oxidative 
      parameters showed that skeletal muscle adapt to increased ROS levels, reducing 
      the risk of free radical damage to the tissue after both exercise protocols. 
      These results show that the effects of physical exercise on skeletal muscle are 
      mediated in an exercise type-dependent manner.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Vilela, Thais Cereser
AU  - Vilela TC
AD  - Laboratory of Molecular and Cellular Biology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil. Electronic address: vilelacthais@gmail.com.
FAU - Effting, Pauline Souza
AU  - Effting PS
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - Dos Santos Pedroso, Giulia
AU  - Dos Santos Pedroso G
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - Farias, Hemelin
AU  - Farias H
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - Paganini, Lara
AU  - Paganini L
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - Rebelo Sorato, Helen
AU  - Rebelo Sorato H
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - Nesi, Renata Tiescoski
AU  - Nesi RT
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - de Andrade, Vanessa Moraes
AU  - de Andrade VM
AD  - Laboratory of Molecular and Cellular Biology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
FAU - de Pinho, Ricardo Aurino
AU  - de Pinho RA
AD  - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health 
      Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), 
      Criciuma, Santa Catarina, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180219
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Glutathione/metabolism
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - *Oxidative Stress
MH  - Physical Conditioning, Animal/*methods
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Aging
OT  - Oxidative stress
OT  - Sarcopenia
OT  - Strength exercise
EDAT- 2018/02/23 06:00
MHDA- 2019/04/24 06:00
CRDT- 2018/02/23 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/02/12 00:00 [revised]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - S0531-5565(18)30033-0 [pii]
AID - 10.1016/j.exger.2018.02.014 [doi]
PST - ppublish
SO  - Exp Gerontol. 2018 Jun;106:21-27. doi: 10.1016/j.exger.2018.02.014. Epub 2018 Feb 
      19.