PMID- 29471245
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 100
DP  - 2018 Apr
TI  - Intraperitoneal administration of mesenchymal stem cells ameliorates acute 
      dextran sulfate sodium-induced colitis by suppressing dendritic cells.
PG  - 426-432
LID - S0753-3322(17)36557-5 [pii]
LID - 10.1016/j.biopha.2018.02.060 [doi]
AB  - Dendritic cells (DCs) have important pathogenic role in the induction and 
      progression of ulcerative colitis (UC), but their role in mesenchymal stem cells 
      (MSCs)-mediated suppression of colon injury and inflammation is not revealed. By 
      using dextran sodium sulfate (DSS)-induced colitis, a well-established murine 
      model of UC, we examined effects of MSCs on phenotype and function of colon 
      infiltrating DCs. Clinical, histological, immunophenotypic analysis and passive 
      transfer of MSCs-primed DCs were used to evaluate capacity of MSC to suppress 
      inflammatory phenotype of DCs in vivo. Additionally, DCs:MSCs interplay was also 
      investigated in vitro, to confirmed in vivo obtained findings. Intraperitoneally 
      administered MSCs (2 x 10(6)) significantly reduced progression of DSS-induced 
      colitis and reduced serum levels of inflammatory cytokines (IL-1beta, IL-12, and 
      IL-6). Passive transfer of in vivo MSCs-primed DCs reduced severity of colitis 
      while passive transfer of MSCs-non-primed DCs aggravated DSS-induced colitis. 
      Through the secretion of immunomodulatory Galectin 3, MSCs, in paracrine manner, 
      down-regulated production of inflammatory cytokines in DCs and attenuated 
      expression of co-stimulatory and major histocompatibility complex class II 
      molecules on their membranes. Taken together, these results indicate that MSCs 
      achieved their beneficial effects in DSS-induced colitis by suppressing 
      inflammatory phenotype of DCs in Gal-3 dependent manner. Therapeutic targeting of 
      DCs by MSCs should be explored in future studies as a useful approach for the 
      treatment of UC.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Nikolic, Aleksandar
AU  - Nikolic A
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia.
FAU - Simovic Markovic, Bojana
AU  - Simovic Markovic B
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia.
FAU - Gazdic, Marina
AU  - Gazdic M
AD  - Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Randall Harrell, C
AU  - Randall Harrell C
AD  - Regenerative Processing Plant, LLC, Palm Harbor, Florida, United States.
FAU - Fellabaum, Crissy
AU  - Fellabaum C
AD  - Regenerative Processing Plant, LLC, Palm Harbor, Florida, United States.
FAU - Jovicic, Nemanja
AU  - Jovicic N
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia.
FAU - Djonov, Valentin
AU  - Djonov V
AD  - Institute of Anatomy, University of Bern, Bern, Switzerland.
FAU - Arsenijevic, Nebojsa
AU  - Arsenijevic N
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia.
FAU - L Lukic, Miodrag
AU  - L Lukic M
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia.
FAU - Stojkovic, Miodrag
AU  - Stojkovic M
AD  - Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia; Spebo Medical, Leskovac, Serbia.
FAU - Volarevic, Vladislav
AU  - Volarevic V
AD  - Department of Microbiology and Immunology, Center for Molecular Medicine and Stem 
      Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 
      Serbia. Electronic address: drvolarevic@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20180222
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Colitis/chemically induced/*immunology/*therapy
MH  - Dendritic Cells/drug effects/*immunology
MH  - Dextran Sulfate/*toxicity
MH  - Injections, Intraperitoneal
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mice
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - DSS-induced colitis
OT  - Dendritic cells
OT  - Mesenchymal stem cells
EDAT- 2018/02/23 06:00
MHDA- 2018/09/01 06:00
CRDT- 2018/02/23 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/02/02 00:00 [revised]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - S0753-3322(17)36557-5 [pii]
AID - 10.1016/j.biopha.2018.02.060 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Apr;100:426-432. doi: 10.1016/j.biopha.2018.02.060. 
      Epub 2018 Feb 22.