PMID- 29471299
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Print)
IS  - 1011-7571 (Linking)
VI  - 27
IP  - 2
DP  - 2018
TI  - The Effect of Allium cepa Extract on Lung Oxidant, Antioxidant, and Immunological 
      Biomarkers in Ovalbumin-Sensitized Rats.
PG  - 122-128
LID - 10.1159/000487885 [doi]
AB  - OBJECTIVES: To evaluate the effects of Allium cepa (A. cepa) on levels of 
      oxidants, antioxidants, and immunological markers in bronchoalveolar lavage 
      fluids (BALF) of sensitized rats. MATERIALS AND METHODS: Oxidant/antioxidant 
      markers and cytokines in BALF of control rats treated with saline (group C), 
      ovalbumin-sensitized rats (group S), rats treated with 1.25 mug/mL dexamethasone 
      and 3 doses of A. cepa extract (35, 70, and 140 mg/kg body weight [BW]/day) (S + 
      AC) were investigated. Comparison of the results between groups was performed 
      using analysis of variance with the Tukey-Kramer post hoc test. RESULTS: The 
      oxidant markers nitrogen dioxide (NO2), nitrate (NO3-), and malondialdehyde 
      (MDA), and immunological markers interleukin (IL)-4 and immunoglobulin E (IgE) 
      were significantly higher, but the antioxidant markers superoxide dismutase 
      (SOD), catalase (CAT), thiol, and interferon (IFN)-gamma, and the IFN-gamma/IL-4 ratio 
      were lower in sensitized rats compared to control rats (p < 0.001 to p < 0.01). 
      Compared to group S, the levels of the following markers were significantly 
      lower: NO2, NO3-, and IgE in groups treated with the A. cepa extract, MDA and 
      IL-4 levels in groups treated with 70 and 140 mg/kg BW/day of the A. cepa 
      extract, and all these markers as well as IFN-gamma in rats treated with 
      dexamethasone (p < 0.001 to p < 0.05). However, there were significantly higher 
      levels of SOD and CAT and an increased IFN-gamma/IL-4 ratio (groups treated with 70 
      and 140 mg/kg BW/day of the A. cepa extract), and levels of thiol and IFN-gamma 
      (group treated with 140 mg/kg BW/day of the A. cepa extract) as well as SOD, CAT, 
      and thiol (dexamethasone-treated group) versus group S (p < 0.00 to p < 0.05). 
      CONCLUSION: A. cepa showed antioxidant and immunomodulatory properties in 
      sensitized rats.
CI  - (c) 2018 The Author(s) Published by S. Karger AG, Basel.
FAU - Marefati, N
AU  - Marefati N
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Eftekhar, N
AU  - Eftekhar N
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Kaveh, M
AU  - Kaveh M
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Boskabadi, J
AU  - Boskabadi J
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Beheshti, F
AU  - Beheshti F
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Boskabady, M H
AU  - Boskabady MH
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180222
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Nitrates)
RN  - 0 (Oxidants)
RN  - 0 (Sulfhydryl Compounds)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9006-59-1 (Ovalbumin)
RN  - 9008-11-1 (Interferons)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antioxidants/*analysis
MH  - Biomarkers/analysis
MH  - Bronchoalveolar Lavage Fluid
MH  - Catalase
MH  - Immunoglobulin E/*analysis
MH  - Interferons
MH  - Interleukin-4/*analysis
MH  - Lung/metabolism
MH  - Male
MH  - Malondialdehyde
MH  - Nitrates
MH  - Nitrogen Dioxide
MH  - Onions/*immunology/*metabolism
MH  - Ovalbumin
MH  - Oxidants
MH  - Oxidoreductases/*analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Sulfhydryl Compounds/analysis
MH  - Superoxide Dismutase
PMC - PMC5968249
OTO - NOTNLM
OT  - Allium cepa
OT  - Antioxidants
OT  - Asthma
OT  - Immunomodulation
EDAT- 2018/02/23 06:00
MHDA- 2018/11/27 06:00
PMCR- 2018/02/22
CRDT- 2018/02/23 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
PHST- 2018/02/22 00:00 [pmc-release]
AID - 000487885 [pii]
AID - mpp-0027-0122 [pii]
AID - 10.1159/000487885 [doi]
PST - ppublish
SO  - Med Princ Pract. 2018;27(2):122-128. doi: 10.1159/000487885. Epub 2018 Feb 22.