PMID- 29471595
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 34
IP  - 5
DP  - 2018 Jul
TI  - Procollagen-III peptide identifies adipose tissue-associated inflammation in type 
      2 diabetes with or without nonalcoholic liver disease.
PG  - e2998
LID - 10.1002/dmrr.2998 [doi]
AB  - BACKGROUND: Procollagen-III peptide (PIIINP) is a marker of fibrosis associated 
      with increased cardiometabolic risk and progression of chronic liver diseases 
      such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its 
      association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The 
      aim of this study was to investigate the relationship among circulating PIIINP 
      levels, metabolic traits, and body fat distribution in subjects with T2DM with or 
      without NAFLD. METHODS: Data from 62 T2DM subjects recruited in our diabetes 
      outpatient clinics at Sapienza University of Rome, Italy, were analysed. 
      Participants underwent metabolic and inflammatory profiling (CRP, TNFalpha, IL-6, 
      IL-8, WISP1, and adiponectin) and magnetic resonance imaging for diagnosing NAFLD 
      on the basis of hepatic fat fraction (>/=5.5%) and quantifying visceral and 
      subcutaneous adipose tissue (AT) areas. Serum PIIINP was measured by human-PIIINP 
      ELISA kits. RESULTS: Higher PIIINP levels correlated with greater BMI and 
      visceral AT area and were associated with systemic signatures of AT-associated 
      inflammation-ie, higher WISP-1, IL-8, and lower adiponectin levels; conversely, 
      PIIINP did not differ significantly between T2DM patients with or without NAFLD 
      and were not associated with hepatic fat fraction, Fatty Liver Index, FIB-4, or 
      transaminases. CONCLUSIONS: Elevated circulating PIIINP levels specifically 
      identify T2DM individuals with AT expansion and systemic proinflammatory profile 
      suggestive for AT dysfunction; our results point toward a new role of PIIINP as a 
      marker of fibroinflammation in dysmetabolic conditions, likely related to AT 
      expansion.
CI  - Copyright (c) 2018 John Wiley & Sons, Ltd.
FAU - Barchetta, I
AU  - Barchetta I
AUID- ORCID: 0000-0003-0530-8568
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Cimini, F A
AU  - Cimini FA
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - De Gioannis, R
AU  - De Gioannis R
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Ciccarelli, G
AU  - Ciccarelli G
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Bertoccini, L
AU  - Bertoccini L
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Lenzi, A
AU  - Lenzi A
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Baroni, M G
AU  - Baroni MG
AUID- ORCID: 0000-0002-3224-6078
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
FAU - Cavallo, M G
AU  - Cavallo MG
AD  - Department of Experimental Medicine, Section of Medical Pathophysiology, Food 
      Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180324
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type III-N-terminal peptide)
SB  - IM
MH  - Adipose Tissue/metabolism/*pathology
MH  - Biomarkers/*blood
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inflammation/blood/*diagnosis/etiology
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*complications
MH  - Peptide Fragments/*blood
MH  - Procollagen/*blood
MH  - Prognosis
OTO - NOTNLM
OT  - adipose tissue
OT  - fatty liver
OT  - fibrosis
OT  - inflammation
OT  - procollagen-III
OT  - type 2 diabetes
EDAT- 2018/02/23 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/02/23 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/01/13 00:00 [revised]
PHST- 2018/02/12 00:00 [accepted]
PHST- 2018/02/23 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/02/23 06:00 [entrez]
AID - 10.1002/dmrr.2998 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2018 Jul;34(5):e2998. doi: 10.1002/dmrr.2998. Epub 2018 
      Mar 24.