PMID- 29472439
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180502
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 182
IP  - 17
DP  - 2018 Apr 28
TI  - Commercial porcine reproductive and respiratory syndrome virus (PRRSV)-2 modified 
      live virus vaccine against heterologous single and dual Korean PRRSV-1 and 
      PRRSV-2 challenge.
PG  - 485
LID - 10.1136/vr.104397 [doi]
AB  - This study evaluated porcine reproductive and respiratory syndrome virus 
      (PRRSV)-2 modified live virus (MLV) vaccine against heterologous single and dual 
      challenge of Korean PRRSV-1 and PRRSV-2. Pigs were administered PRRSV-2 MLV 
      vaccine intramuscularly at 21 days of age and inoculated intranasally with both 
      genotypes at 56 days of age. Vaccination of pigs with PRRSV-2 MLV vaccine 
      resulted in reduction of viral loads of both PRRSV-1 and PRRSV-2 after 
      heterologous single and dual challenge with PRRSV-1 and PRRSV-2. In addition, 
      pigs vaccinated with PRRSV-2 MLV vaccine exhibited higher frequencies of PRRSV-1 
      and PRRSV-2 specific interferon-gamma secreting cells (IFN-gamma-SC) and showed a 
      significant reduction in lung lesions and PRRSV nucleic acid within the lung 
      lesions after single and dual challenge compared with unvaccinated challenged 
      pigs. Taken together these results demonstrated that vaccination of pigs with 
      PRRSV-2 is efficacious in protecting growing pigs from respiratory disease 
      against heterologous single and dual PRRSV-1 and PRRSV-2 challenge.
CI  - (c) British Veterinary Association (unless otherwise stated in the text of the 
      article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Kim, Seeun
AU  - Kim S
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, Seoul National University, College of 
      Veterinary Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180222
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Genotype
MH  - Injections, Intramuscular
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Swine
MH  - Vaccination/methods/*veterinary
MH  - Vaccines, Attenuated/administration & dosage/immunology
MH  - Viral Load/veterinary
MH  - Viral Vaccines/administration & dosage/*immunology
OTO - NOTNLM
OT  - co-infection
OT  - genotype
OT  - porcine reproductive and respiratory syndrome (prrs)
OT  - vaccine
COIS- Competing interests: None declared.
EDAT- 2018/02/24 06:00
MHDA- 2018/05/03 06:00
CRDT- 2018/02/24 06:00
PHST- 2017/03/07 00:00 [received]
PHST- 2017/11/07 00:00 [revised]
PHST- 2018/01/28 00:00 [accepted]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2018/02/24 06:00 [entrez]
AID - vr.104397 [pii]
AID - 10.1136/vr.104397 [doi]
PST - ppublish
SO  - Vet Rec. 2018 Apr 28;182(17):485. doi: 10.1136/vr.104397. Epub 2018 Feb 22.