PMID- 29472625
OWN - NLM
STAT- MEDLINE
DCOM- 20190923
LR  - 20190923
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Feb 22
TI  - The role of medial prefrontal cortex in the working memory maintenance of one's 
      own emotional responses.
PG  - 3460
LID - 10.1038/s41598-018-21896-8 [doi]
LID - 3460
AB  - The role of medial prefrontal cortex (MPFC) in maintaining emotional information 
      within working memory (WM) remains insufficiently investigated - with some 
      studies suggesting this process activates MPFC and others suggesting its activity 
      is suppressed. To reconcile these different results, we asked 26 healthy 
      participants to complete a WM task involving the maintenance of emotional content 
      (EWM), visual content (VWM), or no content ("rest") after exposure to 
      emotion-provoking images. We also assessed individual differences in emotional 
      awareness (EA). We observed that dorsal MPFC was more active during EWM than VWM; 
      further, relative to the rest condition, both of these WM conditions involved 
      suppression of ventral MPFC. We also observed that the dorsal anterior cingulate 
      subregion of dorsal MPFC was positively associated with EA. We discuss how these 
      results may be able to reconcile the findings of previous EWM studies, and extend 
      understanding of the relationship between MPFC, EA, and WM.
FAU - Smith, Ryan
AU  - Smith R
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States. rssmith@email.arizona.edu.
FAU - Lane, Richard D
AU  - Lane RD
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Alkozei, Anna
AU  - Alkozei A
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Bao, Jennifer
AU  - Bao J
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Smith, Courtney
AU  - Smith C
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Sanova, Anna
AU  - Sanova A
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Nettles, Matthew
AU  - Nettles M
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
FAU - Killgore, William D S
AU  - Killgore WDS
AD  - Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave, Tucson, 
      AZ, 85724-5002, United States.
LA  - eng
PT  - Journal Article
DEP - 20180222
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Awareness
MH  - Emotions/*physiology
MH  - Female
MH  - Gyrus Cinguli/*physiology
MH  - Healthy Volunteers
MH  - Humans
MH  - Individuality
MH  - Memory, Short-Term/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rest
MH  - Visual Perception/physiology
PMC - PMC5823866
COIS- The authors declare no competing interests.
EDAT- 2018/02/24 06:00
MHDA- 2019/09/24 06:00
PMCR- 2018/02/22
CRDT- 2018/02/24 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2019/09/24 06:00 [medline]
PHST- 2018/02/22 00:00 [pmc-release]
AID - 10.1038/s41598-018-21896-8 [pii]
AID - 21896 [pii]
AID - 10.1038/s41598-018-21896-8 [doi]
PST - epublish
SO  - Sci Rep. 2018 Feb 22;8(1):3460. doi: 10.1038/s41598-018-21896-8.