PMID- 29472733
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240315
IS  - 0860-021X (Print)
IS  - 2083-1862 (Electronic)
IS  - 0860-021X (Linking)
VI  - 34
IP  - 4
DP  - 2017 Dec
TI  - Androgen interacts with exercise through the mTOR pathway to induce skeletal 
      muscle hypertrophy.
PG  - 313-321
LID - 10.5114/biolsport.2017.69818 [doi]
AB  - This study was designed to investigate the effects of exogenous androgen and 
      resistance exercise on skeletal muscle hypertrophy and the role of the mammalian 
      target of rapamycin (mTOR) signalling during the process. A total of 24 male 
      Sprague-Dawley rats were randomly assigned to sham operation and 
      dihydrotestosterone (DHT) implantation groups with subgroups subjected to 
      sedentary conditions or resistance exercise (SHAM+SED, SHAM+EX, DHT+SED, and 
      DHT+EX). The experimental procedure lasted for 10 days. The mRNA expression of 
      androgen receptor (AR) and insulin-like growth factor I (IGF-I), the expression 
      of myosin heavy chain (MHC), as well as the phosphorylation statuses of AR, mTOR, 
      p70 ribosomal S6 kinase (p70(S6K)), and eukaryotic translation initiation factor 
      4E-binding protein 1 (4EBP1) were determined in the white gastrocnemius muscle. 
      The cross sectional area and wet mass of the muscle were also measured. The cross 
      sectional area and MHC expression were significantly higher in SHAM+EX, DHT+SED, 
      and DHT+EX than in SHAM+SED. There was no significant difference among groups in 
      muscle mass. The mRNA expression of AR and IGF-I and the phosphorylation of mTOR, 
      p70(S6K), and 4EBP1 were significantly increased in DHT+SED and SHAM+EX and were 
      significantly enhanced in DHT+EX compared with either DHT or exercise alone. 
      These data show that DHT causes hypertrophy in skeletal muscle and that exercise 
      has a synergistic effect on DHT-induced hypertrophy. Exercise enhances 
      androgen-induced rapid anabolic action, which involves activation of the mTOR 
      pathway.
FAU - Zeng, Fanxing
AU  - Zeng F
AD  - Department of Exercise Physiology, Beijing Sport University, Beijing 100000, 
      China.
FAU - Zhao, Hua
AU  - Zhao H
AD  - Department of Physical Education, Central China Normal University, Wuhan 430000, 
      China.
FAU - Liao, Jingwen
AU  - Liao J
AD  - Guangdong Provincial Key Laboratory of Sports and Health Promotion, Scientific 
      Research Center, Guangzhou Sport University, Guangzhou 510000, China.
LA  - eng
PT  - Journal Article
DEP - 20170920
PL  - Poland
TA  - Biol Sport
JT  - Biology of sport
JID - 8700872
PMC - PMC5819476
OTO - NOTNLM
OT  - Androgen
OT  - Exercise
OT  - Muscle hypertrophy
OT  - mTOR
COIS- No conflicts of interest, financial or otherwise, are declared by the authors.
EDAT- 2018/02/24 06:00
MHDA- 2018/02/24 06:01
PMCR- 2017/12/01
CRDT- 2018/02/24 06:00
PHST- 2016/10/13 00:00 [received]
PHST- 2017/03/03 00:00 [revised]
PHST- 2017/04/12 00:00 [accepted]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2018/02/24 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 69818 [pii]
AID - 10.5114/biolsport.2017.69818 [doi]
PST - ppublish
SO  - Biol Sport. 2017 Dec;34(4):313-321. doi: 10.5114/biolsport.2017.69818. Epub 2017 
      Sep 20.