PMID- 29472811
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 42
IP  - 4
DP  - 2017
TI  - The influence of KIR gene presence/absence polymorphisms on the development of 
      periodontal disease in smokers and non-smokers.
PG  - 347-353
LID - 10.5114/ceji.2017.72796 [doi]
AB  - INTRODUCTION: Periodontal diseases are highly prevalent inflammatory, 
      multifactorial diseases. Smoking is one of the most important environmental risk 
      factors for the development and severity of periodontal disease. Killer cell 
      immunoglobulin-like receptors (KIRs) are members of the immunoglobulin (Ig) 
      superfamily and play an essential role in the regulation of NK cell activity, 
      allowing natural killer (NK) cells to sense and respond to human leukocyte 
      antigen (HLA) class I. The aim of this study was to evaluate the influence of KIR 
      gene presence/absence polymorphisms on the development of periodontal disease in 
      smokers and non-smokers. MATERIAL AND METHODS: This study enrolled 400 Caucasian 
      subjects (age range 25-69 years) from the West Pomeranian region of Poland. The 
      subjects were categorized into four subgroups (smoking and non-smoking patients 
      with periodontal disease; smoking and non-smoking subjects without periodontal 
      disease - control subjects). RESULTS: The differences of KIR gene frequencies 
      between non-smoking patients and non-smoking control subjects as well as smoking 
      patients and control subjects were not statistically significant. In multivariate 
      regression analysis advanced age of patients and smoking were independent factors 
      associated with increased frequency of periodontal disease. CONCLUSIONS: The 
      results of this study suggest that the main factor associated with increased risk 
      of periodontal disease is smoking, whereas KIR presence/absence polymorphism is 
      not a significant factor involved in the pathogenesis of periodontal disease.
FAU - Mazurek-Mochol, Malgorzata
AU  - Mazurek-Mochol M
AD  - Department of Periodontology, Pomeranian Medical University, Szczecin, Poland.
FAU - Majorczyk, Edyta
AU  - Majorczyk E
AD  - Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, 
      Poland.
FAU - Banach, Jadwiga
AU  - Banach J
AD  - Department of Periodontology, Pomeranian Medical University, Szczecin, Poland.
FAU - Dembowska, Elzbieta
AU  - Dembowska E
AD  - Department of Periodontology, Pomeranian Medical University, Szczecin, Poland.
FAU - Kusnierczyk, Piotr
AU  - Kusnierczyk P
AD  - Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, 
      Poland.
FAU - Safranow, Krzysztof
AU  - Safranow K
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      Szczecin, Poland.
FAU - Pawlik, Andrzej
AU  - Pawlik A
AD  - Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20171230
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC5820974
OTO - NOTNLM
OT  - inhibitory/activating receptors
OT  - killer immunoglobulin-like receptors (KIRs)
OT  - natural killer cells
COIS- The authors declare no conflict of interest.
EDAT- 2018/02/24 06:00
MHDA- 2018/02/24 06:01
PMCR- 2017/01/01
CRDT- 2018/02/24 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2016/12/30 00:00 [accepted]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2018/02/24 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 31512 [pii]
AID - 10.5114/ceji.2017.72796 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2017;42(4):347-353. doi: 10.5114/ceji.2017.72796. Epub 2017 
      Dec 30.