PMID- 29473216
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 96
IP  - 5
DP  - 2018 May
TI  - Homeostatic control of dendritic cell numbers and differentiation.
PG  - 463-476
LID - 10.1111/imcb.12028 [doi]
AB  - Dendritic cells (DCs) are a diverse family of cells that play a crucial role in 
      linking our innate and adaptive immune system to initiate adequate T-cell 
      responses. They respond to pathogens by triggering the appropriate adaptive 
      immune response that is required to clear invaders while balancing the need to 
      limit tissue damage as a result of inflammation. Perturbation in DC regulation 
      results in abnormal T-cell homeostasis, leading to development of autoimmune 
      diseases and aberrant responses to pathogens. In recent years, it has become 
      clear that the DC family is more complex than initially thought in terms of their 
      identification, homeostasis and functions. In this review, we discuss recent 
      findings that improve our understanding of development, and functional 
      specializations of conventional and plasmacytoid DCs.
CI  - (c) 2018 Australasian Society for Immunology Inc.
FAU - Dress, Regine J
AU  - Dress RJ
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research 
      (A*STAR), Singapore, 138648, Singapore.
FAU - Wong, Alicia Yw
AU  - Wong AY
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research 
      (A*STAR), Singapore, 138648, Singapore.
FAU - Ginhoux, Florent
AU  - Ginhoux F
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research 
      (A*STAR), Singapore, 138648, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180323
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Dendritic Cells/*immunology
MH  - Homeostasis
MH  - Humans
MH  - Inflammation/*immunology
MH  - Lymphocyte Activation
MH  - T-Lymphocytes/*immunology
OTO - NOTNLM
OT  - pDC
OT  - DC1
OT  - DC2
OT  - dendritic cell
OT  - development
OT  - differentiation
OT  - ontogeny
OT  - plasmacytoid DC
OT  - steady state
OT  - subset
OT  - transcriptional control
EDAT- 2018/02/24 06:00
MHDA- 2019/06/25 06:00
CRDT- 2018/02/24 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/02/18 00:00 [revised]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/02/24 06:00 [entrez]
AID - 10.1111/imcb.12028 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2018 May;96(5):463-476. doi: 10.1111/imcb.12028. Epub 2018 Mar 
      23.