PMID- 29473761 OWN - NLM STAT- MEDLINE DCOM- 20190128 LR - 20220409 IS - 1525-6006 (Electronic) IS - 1064-1963 (Linking) VI - 41 IP - 1 DP - 2019 TI - Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns. PG - 58-61 LID - 10.1080/10641963.2018.1441861 [doi] AB - Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined. Results showed a strong association between preeclampsia and low birth weight, premature/cesarean delivery and proteinuria (P < 0.001). Hb and neutrophils were significantly lower (P < 0.01), whereas RDW, PCV, MCV, MCH, MCHC and lymphocytes were significantly higher than normal ones (P < 0.01). When cord blood of preeclamptic mothers were compared with that of normal ones, similar findings were observed. In addition, results showed significant and positive correlations between preeclamptic mothers and their newborn in Hb (r2 = 0.075, P < 0.05), PCV (r2 = 0.084, P < 0.01), MCV (r2 = 0.077, P < 0.05), MCHC (r2 = 0.115, P < 0.01), RBC (r2 = 0.086, P < 0.01) and retics (r2 = 0.306, P < 0.01). In conclusion, changes in several hematological parameters associated with preeclampsia were correlated in affected mothers and their newborns. Such biomarkers can be used to predict pregnancy outcomes in women with preeclampsia. FAU - Elgari, Mahmoud M AU - Elgari MM AD - a Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences , Taibah University , Medina , Saudi Arabia. AD - c Faculty of Medical Laboratory Sciences , Sudan University for Sciences and Technology , Khartoum , Sudan. FAU - Khabour, Omar F AU - Khabour OF AUID- ORCID: 0000-0002-3006-3104 AD - a Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences , Taibah University , Medina , Saudi Arabia. AD - b Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences , Jordan University of Science and Technology , Irbid , Jordan. FAU - Alhag, Samaher M AU - Alhag SM AD - c Faculty of Medical Laboratory Sciences , Sudan University for Sciences and Technology , Khartoum , Sudan. AD - d Department of Medical Laboratory , Al- Ghad College of Applied Medical Sciences , Medina , Saudi Arabia. LA - eng PT - Journal Article DEP - 20180223 PL - England TA - Clin Exp Hypertens JT - Clinical and experimental hypertension (New York, N.Y. : 1993) JID - 9305929 RN - 0 (Biomarkers) RN - 0 (Hemoglobins) SB - IM MH - Adolescent MH - Adult MH - Biomarkers/blood MH - *Blood Physiological Phenomena MH - Case-Control Studies MH - Cesarean Section MH - Cross-Sectional Studies MH - Erythrocyte Count MH - Erythrocyte Indices MH - Female MH - Fetal Blood/*cytology/*metabolism MH - Hematocrit MH - Hemoglobins/metabolism MH - Humans MH - Infant, Low Birth Weight MH - Infant, Newborn MH - Lymphocyte Count MH - Mean Platelet Volume MH - Neutrophils MH - Platelet Count MH - Pre-Eclampsia/*blood MH - Pregnancy MH - Premature Birth/etiology MH - Proteinuria/etiology MH - Young Adult OTO - NOTNLM OT - Hypertension OT - biomarkers OT - cord blood OT - preeclampsia OT - pregnancy EDAT- 2018/02/24 06:00 MHDA- 2019/01/29 06:00 CRDT- 2018/02/24 06:00 PHST- 2018/02/24 06:00 [pubmed] PHST- 2019/01/29 06:00 [medline] PHST- 2018/02/24 06:00 [entrez] AID - 10.1080/10641963.2018.1441861 [doi] PST - ppublish SO - Clin Exp Hypertens. 2019;41(1):58-61. doi: 10.1080/10641963.2018.1441861. Epub 2018 Feb 23.