PMID- 29473842
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 23
IP  - 2
DP  - 2018 Feb 23
TI  - Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella 
      radiata Polysaccharides on Alcohol-Induced Liver Injury.
LID - 10.3390/molecules23020481 [doi]
LID - 481
AB  - This work was to examine the antioxidation in vitro and hepatoprotective effects 
      of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on 
      alcohol-induced liver damage in mice. The antioxidant activities were determined 
      according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 
      1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. 
      En-OPS showed hepatoprotective activities on decreasing the serum levels of 
      aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline 
      phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and 
      triacylglycerols (TG). En-OPS treatment reversed the acute impairment induced by 
      alcohol consumption, including reactive oxygen species (ROS) generation, 
      malondialdehyde (MAD), and lipid peroxide (LPO) elevation; and superoxide 
      dismutase (SOD), GSH peroxide (GSH-Px), catalase (CAT), and total antioxidant 
      capacity (T-AOC) impairment. The En-OPS effectively ameliorated alcohol 
      metabolism by activating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase 
      (ALDH), and reducing cytochrome P450 2E1 (CYP2E1) levels. Furthermore, the 
      histopathological observations also displayed that En-OPS could alleviate liver 
      damage. These results indicated that En-OPS could be suitable to be an ingredient 
      of preventing alcoholic liver diseases (ALD). In addition, the preliminary 
      structure characteristics of En-OPS were also analyzed by Fourier transform 
      infrared (FT-IR) spectroscopy and a gas chromatography-flame ionization detector 
      (GC-FID).
FAU - Wang, Xiuxiu
AU  - Wang X
AD  - Institute of Agricultural Resources and Environment, Shandong Academy of 
      Agricultural Science, Key Laboratory of Wastes Matrix Utilization, Ministry of 
      Agriculture, Jinan 250100, China. xiux_wang@163.com.
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      xiux_wang@163.com.
FAU - Liu, Min
AU  - Liu M
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      lmliumin1991@sina.com.cn.
FAU - Zhang, Chen
AU  - Zhang C
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      zhang.chen1@foxmail.com.
FAU - Li, Shangshang
AU  - Li S
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      shangshangli2012@163.com.
FAU - Yang, Qihang
AU  - Yang Q
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      yangqh95@163.com.
FAU - Zhang, Jianjun
AU  - Zhang J
AUID- ORCID: 0000-0002-6308-3873
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      zhangjj@sdau.edu.cn.
FAU - Gong, Zhiyuan
AU  - Gong Z
AD  - Institute of Agricultural Resources and Environment, Shandong Academy of 
      Agricultural Science, Key Laboratory of Wastes Matrix Utilization, Ministry of 
      Agriculture, Jinan 250100, China. sdgzy2656@126.com.
FAU - Han, Jiandong
AU  - Han J
AD  - Institute of Agricultural Resources and Environment, Shandong Academy of 
      Agricultural Science, Key Laboratory of Wastes Matrix Utilization, Ministry of 
      Agriculture, Jinan 250100, China. hanjiandong16@163.com.
FAU - Jia, Le
AU  - Jia L
AUID- ORCID: 0000-0002-6308-3873
AD  - College of Life Science, Shandong Agricultural University, Taian 271018, China. 
      jia__le@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180223
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Monosaccharides)
RN  - 0 (Polysaccharides)
RN  - 0 (Protective Agents)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Agaricales/*chemistry
MH  - Animals
MH  - Antioxidants/*chemistry/*pharmacology
MH  - Biomarkers
MH  - Biopsy
MH  - Disease Models, Animal
MH  - Gas Chromatography-Mass Spectrometry
MH  - Liver Diseases, Alcoholic/drug therapy/*metabolism/pathology
MH  - Liver Function Tests
MH  - Mice
MH  - Monosaccharides/chemistry
MH  - Oxidative Stress/drug effects
MH  - Polysaccharides/*chemistry/*pharmacology
MH  - Protective Agents/*chemistry/*pharmacology
MH  - Reactive Oxygen Species/metabolism
MH  - Spectroscopy, Fourier Transform Infrared
PMC - PMC6017660
OTO - NOTNLM
OT  - alcoholic liver diseases
OT  - antioxidant
OT  - enzyme-extracted Oudemansiella radiata polysaccharides
OT  - hepatoprotective effects
COIS- The authors declare no conflict of interest.
EDAT- 2018/02/24 06:00
MHDA- 2018/08/28 06:00
PMCR- 2018/02/23
CRDT- 2018/02/24 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/02/01 00:00 [revised]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2018/02/23 00:00 [pmc-release]
AID - molecules23020481 [pii]
AID - molecules-23-00481 [pii]
AID - 10.3390/molecules23020481 [doi]
PST - epublish
SO  - Molecules. 2018 Feb 23;23(2):481. doi: 10.3390/molecules23020481.