PMID- 29474122
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20240216
IS  - 1547-6898 (Electronic)
IS  - 1040-8444 (Print)
IS  - 1040-8444 (Linking)
VI  - 48
IP  - 5
DP  - 2018 May
TI  - Non-animal methods to predict skin sensitization (II): an assessment of defined 
      approaches (*).
PG  - 359-374
LID - 10.1080/10408444.2018.1429386 [doi]
AB  - Skin sensitization is a toxicity endpoint of widespread concern, for which the 
      mechanistic understanding and concurrent necessity for non-animal testing 
      approaches have evolved to a critical juncture, with many available options for 
      predicting sensitization without using animals. Cosmetics Europe and the National 
      Toxicology Program Interagency Center for the Evaluation of Alternative 
      Toxicological Methods collaborated to analyze the performance of multiple 
      non-animal data integration approaches for the skin sensitization safety 
      assessment of cosmetics ingredients. The Cosmetics Europe Skin Tolerance Task 
      Force (STTF) collected and generated data on 128 substances in multiple in vitro 
      and in chemico skin sensitization assays selected based on a systematic 
      assessment by the STTF. These assays, together with certain in silico 
      predictions, are key components of various non-animal testing strategies that 
      have been submitted to the Organization for Economic Cooperation and Development 
      as case studies for skin sensitization. Curated murine local lymph node assay 
      (LLNA) and human skin sensitization data were used to evaluate the performance of 
      six defined approaches, comprising eight non-animal testing strategies, for both 
      hazard and potency characterization. Defined approaches examined included 
      consensus methods, artificial neural networks, support vector machine models, 
      Bayesian networks, and decision trees, most of which were reproduced using open 
      source software tools. Multiple non-animal testing strategies incorporating in 
      vitro, in chemico, and in silico inputs demonstrated equivalent or superior 
      performance to the LLNA when compared to both animal and human data for skin 
      sensitization.
FAU - Kleinstreuer, Nicole C
AU  - Kleinstreuer NC
AD  - a NIH/NIEHS/DNTP/NICEATM , Research Triangle Park , NC , USA.
FAU - Hoffmann, Sebastian
AU  - Hoffmann S
AD  - b SEH Consulting + Services , Paderborn , Germany.
FAU - Alepee, Nathalie
AU  - Alepee N
AD  - c L'Oreal Research & Innovation , Aulnay-sous-Bois , France.
FAU - Allen, David
AU  - Allen D
AD  - d ILS , Research Triangle Park , NC , USA.
FAU - Ashikaga, Takao
AU  - Ashikaga T
AD  - e Shiseido , Yokohama-shi , Kanagawa , Japan.
FAU - Casey, Warren
AU  - Casey W
AD  - a NIH/NIEHS/DNTP/NICEATM , Research Triangle Park , NC , USA.
FAU - Clouet, Elodie
AU  - Clouet E
AD  - f Pierre Fabre , Toulouse , France.
FAU - Cluzel, Magalie
AU  - Cluzel M
AD  - g LVMH , St Jean de Braye , France.
FAU - Desprez, Bertrand
AU  - Desprez B
AD  - h Cosmetics Europe , Brussels , Belgium.
FAU - Gellatly, Nichola
AU  - Gellatly N
AD  - i Unilever , London , UK.
FAU - Gobel, Carsten
AU  - Gobel C
AD  - j Coty , Darmstadt , Germany.
FAU - Kern, Petra S
AU  - Kern PS
AD  - k Procter & Gamble Services Company NV , Strombeek-Bever , Belgium.
FAU - Klaric, Martina
AU  - Klaric M
AD  - h Cosmetics Europe , Brussels , Belgium.
FAU - Kuhnl, Jochen
AU  - Kuhnl J
AD  - l Beiersdorf AG , Hamburg , Germany.
FAU - Martinozzi-Teissier, Silvia
AU  - Martinozzi-Teissier S
AD  - c L'Oreal Research & Innovation , Aulnay-sous-Bois , France.
FAU - Mewes, Karsten
AU  - Mewes K
AD  - m Henkel AG & Co. KGaA , Dusseldorf , Germany.
FAU - Miyazawa, Masaaki
AU  - Miyazawa M
AD  - n Kao Corporation , Haga , Tochigi , Japan.
FAU - Strickland, Judy
AU  - Strickland J
AD  - d ILS , Research Triangle Park , NC , USA.
FAU - van Vliet, Erwin
AU  - van Vliet E
AD  - o Services & Consultations on Alternative Methods (SeCAM) , Magliaso , 
      Switzerland.
FAU - Zang, Qingda
AU  - Zang Q
AD  - d ILS , Research Triangle Park , NC , USA.
FAU - Petersohn, Dirk
AU  - Petersohn D
AD  - m Henkel AG & Co. KGaA , Dusseldorf , Germany.
LA  - eng
GR  - HHSN273201500010C/ES/NIEHS NIH HHS/United States
GR  - Z99 ES999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180223
PL  - England
TA  - Crit Rev Toxicol
JT  - Critical reviews in toxicology
JID - 8914275
RN  - 0 (Cosmetics)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Computational Biology/*methods
MH  - *Computer Simulation
MH  - Cosmetics/*adverse effects/pharmacology
MH  - Dermatitis, Allergic Contact/etiology/*immunology
MH  - Humans
MH  - Mice
MH  - Skin/drug effects/*immunology
PMC - PMC7393691
MID - NIHMS1505204
OTO - NOTNLM
OT  - LLNA reference data
OT  - Skin sensitization
OT  - adverse outcome pathway
OT  - defined approaches
OT  - hazard assessment
OT  - human reference data
OT  - integrated testing strategy
OT  - new approach methodologies
OT  - potency assessment
EDAT- 2018/02/24 06:00
MHDA- 2019/06/25 06:00
PMCR- 2020/07/31
CRDT- 2018/02/24 06:00
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2020/07/31 00:00 [pmc-release]
AID - 10.1080/10408444.2018.1429386 [doi]
PST - ppublish
SO  - Crit Rev Toxicol. 2018 May;48(5):359-374. doi: 10.1080/10408444.2018.1429386. 
      Epub 2018 Feb 23.