PMID- 29474128
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1547-6898 (Electronic)
IS  - 1040-8444 (Linking)
VI  - 48
IP  - 5
DP  - 2018 May
TI  - Non-animal methods to predict skin sensitization (I): the Cosmetics Europe 
      database<sup/>.
PG  - 344-358
LID - 10.1080/10408444.2018.1429385 [doi]
AB  - Cosmetics Europe, the European Trade Association for the cosmetics and personal 
      care industry, is conducting a multi-phase program to develop regulatory 
      accepted, animal-free testing strategies enabling the cosmetics industry to 
      conduct safety assessments. Based on a systematic evaluation of test methods for 
      skin sensitization, five non-animal test methods (DPRA (Direct Peptide Reactivity 
      Assay), KeratinoSens(TM), h-CLAT (human cell line activation test), U-SENS(TM), 
      SENS-IS) were selected for inclusion in a comprehensive database of 128 
      substances. Existing data were compiled and completed with newly generated data, 
      the latter amounting to one-third of all data. The database was complemented with 
      human and local lymph node assay (LLNA) reference data, physicochemical 
      properties and use categories, and thoroughly curated. Focused on the 
      availability of human data, the substance selection resulted nevertheless 
      resulted in a high diversity of chemistries in terms of physico-chemical property 
      ranges and use categories. Predictivities of skin sensitization potential and 
      potency, where applicable, were calculated for the LLNA as compared to human data 
      and for the individual test methods compared to both human and LLNA reference 
      data. In addition, various aspects of applicability of the test methods were 
      analyzed. Due to its high level of curation, comprehensiveness, and completeness, 
      we propose our database as a point of reference for the evaluation and 
      development of testing strategies, as done for example in the associated work of 
      Kleinstreuer et al. We encourage the community to use it to meet the challenge of 
      conducting skin sensitization safety assessment without generating new animal 
      data.
FAU - Hoffmann, Sebastian
AU  - Hoffmann S
AD  - a seh consulting + services , Paderborn , Germany.
FAU - Kleinstreuer, Nicole
AU  - Kleinstreuer N
AD  - b NIH/NIEHS/DNTP/NICEATM , Research Triangle Park , NC , USA.
FAU - Alepee, Nathalie
AU  - Alepee N
AD  - c L'Oreal Research and Innovation , Aulnay-sous-Bois , France.
FAU - Allen, David
AU  - Allen D
AD  - d ILS, Research Triangle Park , NC , USA.
FAU - Api, Anne Marie
AU  - Api AM
AD  - e The Research Institute for Fragrance Materials (RIFM) , Woodcliff Lake , NJ , 
      USA.
FAU - Ashikaga, Takao
AU  - Ashikaga T
AD  - f Shiseido Global Innovation Center , Hayabuchi , Kanagawa , Japan.
FAU - Clouet, Elodie
AU  - Clouet E
AD  - g Pierre Fabre , Toulouse , France.
FAU - Cluzel, Magalie
AU  - Cluzel M
AD  - h LVMH , St Jean de Braye , France.
FAU - Desprez, Bertrand
AU  - Desprez B
AD  - i Cosmetics Europe , Brussels , Belgium.
FAU - Gellatly, Nichola
AU  - Gellatly N
AD  - j Unilever , Bedford , United Kingdom.
FAU - Goebel, Carsten
AU  - Goebel C
AD  - k Coty , Darmstadt , Germany.
FAU - Kern, Petra S
AU  - Kern PS
AD  - l Procter and Gamble Services Company NV , Strombeek-Bever , Belgium.
FAU - Klaric, Martina
AU  - Klaric M
AD  - i Cosmetics Europe , Brussels , Belgium.
FAU - Kuhnl, Jochen
AU  - Kuhnl J
AD  - m Beiersdorf AG , Hamburg , Germany.
FAU - Lalko, Jon F
AU  - Lalko JF
AD  - e The Research Institute for Fragrance Materials (RIFM) , Woodcliff Lake , NJ , 
      USA.
FAU - Martinozzi-Teissier, Silvia
AU  - Martinozzi-Teissier S
AD  - c L'Oreal Research and Innovation , Aulnay-sous-Bois , France.
FAU - Mewes, Karsten
AU  - Mewes K
AD  - n Henkel AG and Co. KG , Dusseldorf , Germany.
FAU - Miyazawa, Masaaki
AU  - Miyazawa M
AD  - o Kao Corporation , Tochigi , Japan.
FAU - Parakhia, Rahul
AU  - Parakhia R
AD  - e The Research Institute for Fragrance Materials (RIFM) , Woodcliff Lake , NJ , 
      USA.
FAU - van Vliet, Erwin
AU  - van Vliet E
AD  - p Services and Consultations on Alternative Methods (SeCAM) , Magliaso , 
      Switzerland.
FAU - Zang, Qingda
AU  - Zang Q
AD  - d ILS, Research Triangle Park , NC , USA.
FAU - Petersohn, Dirk
AU  - Petersohn D
AD  - n Henkel AG and Co. KG , Dusseldorf , Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180223
PL  - England
TA  - Crit Rev Toxicol
JT  - Critical reviews in toxicology
JID - 8914275
RN  - 0 (Cosmetics)
SB  - IM
MH  - Animal Testing Alternatives/methods
MH  - Cosmetics/*adverse effects/pharmacology
MH  - *Databases, Factual
MH  - Dermatitis, Allergic Contact/etiology/*immunology
MH  - Humans
MH  - Skin/drug effects/*immunology
OTO - NOTNLM
OT  - LLNA
OT  - Skin sensitization
OT  - database
OT  - defined approach
OT  - human reference data
OT  - in chemico
OT  - in vitro
OT  - non-animal
OT  - test methods
OT  - testing strategy
EDAT- 2018/02/24 06:00
MHDA- 2019/06/25 06:00
CRDT- 2018/02/24 06:00
PHST- 2018/02/24 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/02/24 06:00 [entrez]
AID - 10.1080/10408444.2018.1429385 [doi]
PST - ppublish
SO  - Crit Rev Toxicol. 2018 May;48(5):344-358. doi: 10.1080/10408444.2018.1429385. 
      Epub 2018 Feb 23.