PMID- 29474610
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2058-1742 (Electronic)
IS  - 2058-1742 (Linking)
VI  - 2
IP  - 3
DP  - 2016 Jul 1
TI  - Functional performance and quality of life in high-risk comorbid patients 
      undergoing transcatheter aortic valve implantation for symptomatic aortic valve 
      stenosis.
PG  - 184-192
LID - 10.1093/ehjqcco/qcw001 [doi]
AB  - AIMS: We assessed the impact of transcatheter aortic valve implantation (TAVI) on 
      functional performance and quality of life (QoL) in a high-risk patient 
      population with multiple comorbidities. METHODS AND RESULTS: Between January 2009 
      and December 2014, 145 high-risk patients (EuroSCORE II 7.3% [4.9; 14.9]) with 
      severe symptomatic aortic valve stenosis (AS) underwent TAVI in a single centre. 
      We prospectively evaluated New York Heart Association (NYHA) functional class, 
      6-minute walking distance (6MWD), and QoL using the validated Dutch version of 
      the EuroQol-5D (EQ-5D) descriptive assessment and a visual analogue scale 
      (EQ-VAS) at baseline, 30 days, as well as 6, 12, and 24 months after TAVI. All 
      patients were eligible for analysis. New York Heart Association functional class 
      improved significantly at 30-day, 6-, 12-, and 24-month follow-up (P < 0.001 for 
      all). The absolute 6MWD improved significantly at 30 days (+19.3 +/- 8.2 m; P= 
      0.0499) and at 6 months (+23.3 +/- 8.1 m; P = 0.0194). A favourable trend was 
      maintained at 12 months (+17.1 +/- 8.8 m; P = 0.1879), whereas at 24 months 6MWD 
      was similar to baseline values. No significant change in the descriptive 
      assessment of QoL (EQ5D) was observed, whereas the EQ-VAS showed a significant 
      improvement in QoL up to 24 months (P < 0.0180 for all time-points). CONCLUSION: 
      In high-risk comorbid patients with symptomatic AS, TAVI results in a significant 
      but temporary improvement of functional performance when assessed with objective 
      measures of 6MWD but not of EQ-5D. Moreover, TAVI has a significant and sustained 
      impact on subjective well-being and exercise capacity assessed with the EQ-VAS 
      and NYHA score.
FAU - Hiltrop, Nick
AU  - Hiltrop N
AD  - Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 
      49, Leuven, Belgium.
FAU - Belmans, Ann
AU  - Belmans A
AD  - Department of Public Health, Biostatistical Centre, Katholieke Universiteit 
      Leuven, Leuven, Belgium.
FAU - Claes, Marina
AU  - Claes M
AD  - Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 
      49, Leuven, Belgium.
FAU - Hornikx, Miek
AU  - Hornikx M
AD  - Department of Physical Medicine and Rehabilitation, Katholieke Universiteit 
      Leuven, Leuven, Belgium.
FAU - Peeters, Bart
AU  - Peeters B
AD  - Department of Physical Medicine and Rehabilitation, Katholieke Universiteit 
      Leuven, Leuven, Belgium.
FAU - Flamaing, Johan
AU  - Flamaing J
AD  - Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium.
AD  - Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven, 
      Leuven, Belgium.
FAU - Adriaenssens, Tom
AU  - Adriaenssens T
AD  - Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 
      49, Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, 
      Belgium.
FAU - De Praetere, Herbert
AU  - De Praetere H
AD  - Department of Cardiovascular Surgery, University Hospitals Leuven, Leuven, 
      Belgium.
FAU - Herregods, Marie-Christine
AU  - Herregods MC
AD  - Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 
      49, Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, 
      Belgium.
FAU - Herijgers, Paul
AU  - Herijgers P
AD  - Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, 
      Belgium.
AD  - Department of Cardiovascular Surgery, University Hospitals Leuven, Leuven, 
      Belgium.
FAU - Dubois, Christophe
AU  - Dubois C
AD  - Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 
      49, Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, 
      Belgium.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Qual Care Clin Outcomes
JT  - European heart journal. Quality of care & clinical outcomes
JID - 101677796
EDAT- 2016/07/01 00:00
MHDA- 2016/07/01 00:01
CRDT- 2018/02/24 06:00
PHST- 2015/10/22 00:00 [received]
PHST- 2018/02/24 06:00 [entrez]
PHST- 2016/07/01 00:00 [pubmed]
PHST- 2016/07/01 00:01 [medline]
AID - 2197091 [pii]
AID - 10.1093/ehjqcco/qcw001 [doi]
PST - ppublish
SO  - Eur Heart J Qual Care Clin Outcomes. 2016 Jul 1;2(3):184-192. doi: 
      10.1093/ehjqcco/qcw001.