PMID- 29475928
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181113
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 32
IP  - 2
DP  - 2018 Mar-Apr
TI  - Tear Film Osmolarity in Subjects with Acute Allergic Rhinoconjunctivitis.
PG  - 403-408
AB  - BACKGROUND/AIM: Acute allergic rhinoconjuctivitis is the most common form of 
      ocular allergies. The pathogenetic mechanisms are based on an immunoglobulin E 
      (IgE)-mediated hypersensitivity reaction. On the other hand, tear osmolarity has 
      been suggested to be an index of ocular surface damage and inflammation. These 
      data were the motive to investigate the levels of tear osmolarity in subjects 
      with acute allergic rhinoconjuctivitis, before and after administration of 
      artificial tears. PATIENTS AND METHODS: Forty-five subjects with acute allergic 
      rhinoconjuctivitis were randomly divided into three groups, based on the type of 
      artificial tears that they received: Group A (Thera tears), Group B (Wet therapy) 
      and Group C (Tears Naturale free). The eye drops were administered six times a 
      day for 60 days and all subjects underwent grading of subjective symptoms and 
      clinical examination at baseline and at the end of the treatment. RESULTS: The 
      diagnosis of severe eye disease, which was based on ocular surface disease index 
      (OSDI; Allergan, Inc, Irvine, CA, USA) and tear osmolarity values, concerned all 
      patients at baseline. Although the administration of artificial tears 
      significantly ameliorated the symptoms and the ocular variables in all groups, 
      the results were better in the first group. Tear osmolarity was strongly and 
      negatively correlated with tear film breakup time (BUT) and Schirmer I test at 2 
      months. Contrariwise, symptoms were eliminated, when tear osmolarity was 
      decreased. CONCLUSION: Acute allergic rhinoconjuctivitis is characterized by tear 
      hyperosmolarity, which can be rehabilitated with the administration of hypotonic 
      artificial tears.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Nitoda, Eirini
AU  - Nitoda E
AD  - First Department of Ophthalmology, General Hospital of Athens G. Gennimatas, 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Lavaris, Anastasios
AU  - Lavaris A
AD  - First Department of Ophthalmology, General Hospital of Athens G. Gennimatas, 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Laios, Konstantinos
AU  - Laios K
AD  - First Department of Ophthalmology, General Hospital of Athens G. Gennimatas, 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Androudi, Sophia
AU  - Androudi S
AD  - Department of Ophthalmology, University of Thessaly, Larissa, Greece.
FAU - Kalogeropoulos, Chris D
AU  - Kalogeropoulos CD
AD  - Department of Ophtalmology, Medical School, University of Ioannina, Ioannina, 
      Greece.
FAU - Tsatsos, Michael
AU  - Tsatsos M
AD  - Department of Ophthalmology, University Hospital Southampton, Southampton, U.K.
FAU - Damaskos, Christos
AU  - Damaskos C
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
AD  - N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical 
      School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Garmpis, Nikolaos
AU  - Garmpis N
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece.
AD  - N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical 
      School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Moschos, Marilita M
AU  - Moschos MM
AD  - First Department of Ophthalmology, General Hospital of Athens G. Gennimatas, 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece 
      moschosmarilita@yahoo.fr.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Conjunctivitis, Allergic/*immunology/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - *Osmolar Concentration
MH  - Rhinitis, Allergic/*immunology/*metabolism
MH  - Tears/*chemistry
PMC - PMC5905213
OTO - NOTNLM
OT  - Acute allergic rhinoconjuctivitis
OT  - artificial tears
OT  - tear osmolarity
EDAT- 2018/02/25 06:00
MHDA- 2018/08/28 06:00
PMCR- 2018/03/03
CRDT- 2018/02/25 06:00
PHST- 2017/12/05 00:00 [received]
PHST- 2018/01/07 00:00 [revised]
PHST- 2018/01/11 00:00 [accepted]
PHST- 2018/02/25 06:00 [entrez]
PHST- 2018/02/25 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2018/03/03 00:00 [pmc-release]
AID - 32/2/403 [pii]
AID - 10.21873/invivo.11253 [doi]
PST - ppublish
SO  - In Vivo. 2018 Mar-Apr;32(2):403-408. doi: 10.21873/invivo.11253.