PMID- 29477355
OWN - NLM
STAT- MEDLINE
DCOM- 20190410
LR  - 20210602
IS  - 2530-0180 (Electronic)
IS  - 2530-0180 (Linking)
VI  - 65
IP  - 6
DP  - 2018 Jun-Jul
TI  - Histopathological differences in patients with biopsy-proven non-alcoholic fatty 
      liver disease with and without type 2 diabetes.
PG  - 354-360
LID - S2530-0164(18)30018-1 [pii]
LID - 10.1016/j.endinu.2017.12.011 [doi]
AB  - BACKGROUND AND AIMS: Prevalence of non-alcoholic fatty liver disease (NAFLD) in 
      developed countries is 30% in the general population and 50% in patients with 
      type 2 diabetes mellitus (T2DM). The aim of this study was to compare the 
      severity of NAFLD, as assessed by liver biopsy and using the non-invasive index 
      NAFLD Fibrosis Score (NFS), in subjects with and without T2DM. PATIENTS AND 
      METHODS: The study sample consisted of 217 patients with biopsy-proven NAFLD. 
      Anthropometric assessments, laboratory tests, histological criteria established 
      by the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN), and 
      the NFS were recorded. RESULTS: Patients with T2DM (n=36; 16.5%) had higher 
      HOMA-IR values (6.3+/-3.6 vs. 3.3+/-2.4; p<0.0001), GGT levels (125.2+/-102.3 vs. 
      82.5+/-70.6IU/l; p<005), and NFS index (-0.6+/-0.2 vs. -1.8+/-0.1; p<0.001) than 
      subjects with no T2DM. Patients with T2DM were found higher rates of NASH (72.2% 
      vs. 48.6%; p<0.05), advanced steatosis (80.6% vs. 63%; p<0.05), and liver 
      fibrosis (75% vs. 43.1%, p<0.05) than patients with no T2DM. Patients with T2DM 
      also had higher NFS values (-0.6+/-1.2 vs. -1.8+/-1.8: p=0.01). A logistic regression 
      analysis adjusting for age, gender and BMI showed a significant independent 
      association between NASH and presence of T2DM (OR=4.2: 95% CI: 1.4-12.1; 
      p=0.007). A second model adjusting for the same covariates showed T2DM to be an 
      independent factor associated to advanced fibrosis (OR=4.1; 95% CI: 1.7-9.7). 
      CONCLUSION: Patients with T2DM have more advanced degrees of NAFLD and advanced 
      fibrosis as assessed by liver biopsy and the NFS index. Particular attention 
      should be paid to the study and monitoring of NASH in patients with T2DM.
CI  - Copyright (c) 2018 SEEN y SED. Publicado por Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Aller de la Fuente, Rocio
AU  - Aller de la Fuente R
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain. Electronic 
      address: roaller@yahoo.es.
FAU - Mora Cuadrado, Natalia
AU  - Mora Cuadrado N
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain.
FAU - Tafur, Carla
AU  - Tafur C
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain.
FAU - Lopez Gomez, Juan Jose
AU  - Lopez Gomez JJ
AD  - Hospital Clinico Universitario, Center of Investigation of Endocrinology and 
      Nutrition, Medicine School and Dept of Endocrinology and Nutrition, Valladolid, 
      Spain.
FAU - Gomez de la Cuesta, Sara
AU  - Gomez de la Cuesta S
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain.
FAU - Garcia Sanchez, Maria Concepcion
AU  - Garcia Sanchez MC
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain.
FAU - Antolin Melero, Beatriz
AU  - Antolin Melero B
AD  - Hospital Clinico Universitario, Gastroenterology, Valladolid, Spain.
FAU - de Luis Roman, Daniel Antonio
AU  - de Luis Roman DA
AD  - Hospital Clinico Universitario, Center of Investigation of Endocrinology and 
      Nutrition, Medicine School and Dept of Endocrinology and Nutrition, Valladolid, 
      Spain.
LA  - eng
LA  - spa
PT  - Comparative Study
PT  - Journal Article
DEP - 20180221
PL  - Spain
TA  - Endocrinol Diabetes Nutr (Engl Ed)
JT  - Endocrinologia, diabetes y nutricion
JID - 101717565
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/complications/*pathology
MH  - Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/complications/*pathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Diabetes mellitus tipo 2
OT  - Enfermedad hepatica no alcoholica
OT  - Fibrosis hepatica
OT  - Histopathology
OT  - Histopatologia
OT  - Liver fibrosis
OT  - Non-alcoholic fatty liver disease
OT  - Type 2 diabetes mellitus
EDAT- 2018/02/27 06:00
MHDA- 2019/04/11 06:00
CRDT- 2018/02/26 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2017/12/13 00:00 [revised]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2019/04/11 06:00 [medline]
PHST- 2018/02/26 06:00 [entrez]
AID - S2530-0164(18)30018-1 [pii]
AID - 10.1016/j.endinu.2017.12.011 [doi]
PST - ppublish
SO  - Endocrinol Diabetes Nutr (Engl Ed). 2018 Jun-Jul;65(6):354-360. doi: 
      10.1016/j.endinu.2017.12.011. Epub 2018 Feb 21.