PMID- 29477570
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190501
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 114
DP  - 2018 May
TI  - Persistent organic pollutants and risk of type 2 diabetes: A prospective 
      investigation among middle-aged women in Nurses' Health Study II.
PG  - 334-342
LID - S0160-4120(17)31299-0 [pii]
LID - 10.1016/j.envint.2017.12.010 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) may predispose to 
      the development of type 2 diabetes (T2D), but prospective human evidence is 
      scarce. OBJECTIVES: We investigated the association between plasma-POP 
      concentrations in the late 1990s and incident T2D over 11 years of follow-up in 
      the Nurses' Health Study II. DISCUSSION: Three organochlorine pesticides and 20 
      polychlorinated biphenyls (PCBs) were measured in banked plasma from 793 
      case-control pairs of T2D. In a multiviarate-adjusted model, T2D ORs (95%CIs) 
      comparing extreme POP tertiles (high vs. low) were 1.67 (1.24, 2.23; 
      P(trend) < 0.001) for hexachlorobenzene (HCB), 3.62 (2.57, 5.11; 
      P(trend) < 0.001) for beta-hexachlorocyclohexane (beta-HCH), 1.55 (1.13, 2.13; 
      P(trend) = 0.05) for p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and 1.95 
      (1.42, 2.69; P(trend) < 0.001) for total dioxin-like PCBs (DL-PCBs) which 
      included 5 mono-ortho congeners, PCB-105, 118, 156, 157, and 167. Adjustment for 
      previous weight change and body mass index (BMI) at blood draw attenuated these 
      associations, but that for DL-PCBs remained (OR[95% CI] = 1.78[1.14, 2.76]; 
      P(trend) = 0.006). Age, breastfeeding history, previous weight change and BMI at 
      blood draw were significant predictors of plasma POP concentrations. In addition, 
      we found significant interactions of POPs and weight change before blood draw on 
      T2D risk. ORs (95%CIs) of T2D comparing extreme (high vs. low) POP groups were 
      2.00 (1.02, 3.92; P(trend) = 0.01) for HCB, 2.69 (1.34, 5.40; P(trend) < 0.001) 
      for beta-HCH, and 2.41 (1.22, 4.77; P(trend) < 0.001) for DL-PCBs in the lowest 
      weight gain group, whereas these values were 1.29 (0.73, 2.28; P(trend) = 0.46; 
      P(interaction) = 0.04) for HCB, 1.41 (0.77, 2.60; P(trend) = 0.24; 
      P(interaction) = 0.003) for beta-HCH, and 0.90 (0.50, 1.63; P(trend) = 0.61; 
      P(interaction) = 0.01) for DL-PCBs in the highest weight-gain group. CONCLUSIONS: 
      Our findings suggest that elevated POP exposure may have diabetogenic potential. 
      These data also highlight the impact of lifestyle factors, especially history of 
      weight gain, on circulating POP concentrations and their associations with 
      subsequent T2D risk.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Zong, Geng
AU  - Zong G
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, United States.
FAU - Valvi, Damaskini
AU  - Valvi D
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States.
FAU - Coull, Brent
AU  - Coull B
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States; Department of Biostatistics, Harvard T.H. Chan 
      School of Public Health, Boston, MA 02115, United States.
FAU - Goen, Thomas
AU  - Goen T
AD  - Institute and Outpatient Clinic of Occupational, Social and Environmental 
      Medicine, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.
FAU - Hu, Frank B
AU  - Hu FB
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, United States; Department of Epidemiology, Harvard T.H. Chan School of 
      Public Health, Boston, MA 02115, United States; Channing Division of Network 
      Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard 
      Medical School, Boston, MA 02115, United States.
FAU - Nielsen, Flemming
AU  - Nielsen F
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, United States; Department of Environmental Health, Harvard T.H. Chan 
      School of Public Health, Boston, MA 02115, United States.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States; Institute of Public Health, University of 
      Southern Denmark, Odense, Denmark.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, United States; Channing Division of Network Medicine, Department of 
      Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 
      02115, United States. Electronic address: qisun@hsph.harvard.edu.
LA  - eng
GR  - R01 CA050385/CA/NCI NIH HHS/United States
GR  - R01 DK058785/DK/NIDDK NIH HHS/United States
GR  - R01 ES021372/ES/NIEHS NIH HHS/United States
GR  - R01 DK058845/DK/NIDDK NIH HHS/United States
GR  - R56 DK058785/DK/NIDDK NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - R01 CA067262/CA/NCI NIH HHS/United States
GR  - U01 CA067262/CA/NCI NIH HHS/United States
GR  - R01 ES022981/ES/NIEHS NIH HHS/United States
GR  - R01 DK082486/DK/NIDDK NIH HHS/United States
GR  - R01 CA049449/CA/NCI NIH HHS/United States
GR  - U01 CA049449/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180222
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Environmental Exposure/*analysis/*statistics & numerical data
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Hydrocarbons, Chlorinated
MH  - Middle Aged
MH  - Nurses/*statistics & numerical data
MH  - Prospective Studies
PMC - PMC5899920
MID - NIHMS948017
OTO - NOTNLM
OT  - Persistent organic pollutant
OT  - Type 2 diabetes
OT  - Weight change
COIS- Competing financial interests: The authors declare they have no actual or 
      potential competing financial interests.
EDAT- 2018/02/27 06:00
MHDA- 2019/01/08 06:00
PMCR- 2019/05/01
CRDT- 2018/02/26 06:00
PHST- 2017/07/23 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/12/07 00:00 [accepted]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/02/26 06:00 [entrez]
PHST- 2019/05/01 00:00 [pmc-release]
AID - S0160-4120(17)31299-0 [pii]
AID - 10.1016/j.envint.2017.12.010 [doi]
PST - ppublish
SO  - Environ Int. 2018 May;114:334-342. doi: 10.1016/j.envint.2017.12.010. Epub 2018 
      Feb 22.