PMID- 29477993
OWN - NLM
STAT- MEDLINE
DCOM- 20180912
LR  - 20200223
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2018
DP  - 2018 Feb 23
TI  - First case of acute granulomatous interstitial nephritis with immune 
      reconstitution inflammatory syndrome in a patient with HIV coinfected with 
      disseminated Mycobacterium kansasii.
LID - bcr-2017-222149 [pii]
LID - 10.1136/bcr-2017-222149 [doi]
LID - bcr2017222149
AB  - Restoration of immune response by highly active antiretroviral therapy (HAART) 
      effectively improved the overall prognosis of HIV infection. However, 25%-31.7% 
      of patients experience paradoxical worsening of pre-existing infections or 
      unmasking of subclinical infections after starting HAART therapy, which is termed 
      as immune reconstitution inflammatory syndrome (IRIS). Acute granulomatous 
      interstitial nephritis as a consequence of IRIS has never been reported with 
      Mycobacteriumkansasiicoinfection. Here, we describe an HIV/AIDS patient 
      coinfected with disseminated M. kansasii infection, who presented with acute 
      kidney injury 4.5 months after initiation of HAART. The diagnostic workup 
      revealed IRIS was the cause of acute kidney injury. Short-term course of 
      prednisone (1 mg/kg/day) along with antimycobacterial and HAART regimen achieved 
      significant improvement.
CI  - (c) BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 
      2018. All rights reserved. No commercial use is permitted unless otherwise 
      expressly granted.
FAU - Kapoor, Vikas
AU  - Kapoor V
AD  - Department of Hematology and Oncology, University of Arizona Arizona Health 
      Sciences Center, Tucson, Arizona, USA.
FAU - Latif, Azka
AU  - Latif A
AD  - Department of Hematology and Oncology, University of Arizona Arizona Health 
      Sciences Center, Tucson, Arizona, USA.
FAU - Warraich, Faiza Hassan
AU  - Warraich FH
AD  - Department of Hematology and Oncology, University of Arizona Arizona Health 
      Sciences Center, Tucson, Arizona, USA.
FAU - Majeed, Aneela
AU  - Majeed A
AD  - Department of Infectious Diseases, University of Arizona Arizona Health Sciences 
      Center, Tucson, Arizona, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180223
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Anti-Inflammatory Agents)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/drug therapy
MH  - Acute Disease
MH  - Acute Kidney Injury/complications/drug therapy
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - *Antiretroviral Therapy, Highly Active
MH  - Coinfection/*complications/drug therapy
MH  - Diagnosis, Differential
MH  - HIV Infections/*complications/drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium Infections, Nontuberculous/*complications/drug therapy
MH  - Mycobacterium kansasii/isolation & purification
MH  - Nephritis, Interstitial/*complications/drug therapy
MH  - Prednisone/therapeutic use
PMC - PMC5847901
OTO - NOTNLM
OT  - acute renal failure
OT  - immunology
OT  - infections
OT  - infectious diseases
COIS- Competing interests: None declared.
EDAT- 2018/02/27 06:00
MHDA- 2018/09/13 06:00
PMCR- 2020/02/23
CRDT- 2018/02/26 06:00
PHST- 2018/02/26 06:00 [entrez]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2018/09/13 06:00 [medline]
PHST- 2020/02/23 00:00 [pmc-release]
AID - bcr-2017-222149 [pii]
AID - 10.1136/bcr-2017-222149 [doi]
PST - epublish
SO  - BMJ Case Rep. 2018 Feb 23;2018:bcr2017222149. doi: 10.1136/bcr-2017-222149.