PMID- 29478298
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 18
IP  - 9
DP  - 2018 Sep
TI  - Functional Fc gamma receptor gene polymorphisms and donor-specific 
      antibody-triggered microcirculation inflammation.
PG  - 2261-2273
LID - 10.1111/ajt.14710 [doi]
AB  - Fc-dependent effector mechanisms may contribute to antibody-mediated rejection 
      (ABMR), and distinct gene polymorphisms modifying the function of Fc gamma 
      receptors (FcgammaRs) may influence the capability of donor-specific antibodies 
      (DSAs) to trigger inflammation. To evaluate the relevance of functional FcgammaR 
      variants in late ABMR, 85 DSA-positive kidney allograft recipients, who were 
      recruited upon antibody screening of 741 prevalent patients, were genotyped for 
      polymorphisms in FcgammaRIIA (FCGR2A-H/R(131) ; rs1801274), FcgammaRIIIA (FCGR3A-V/F(158) 
      ; rs396991), and FcgammaRIIIB (FCGR3B-neutrophil antigen 1 ([NA1]/NA2; rs35139848). 
      Individuals with high-affinity FCGR3A-V(158) alleles (V/V(158) or V/F(158) ) 
      showed a higher rate (and extent) of peritubular capillaritis (ptc) in protocol 
      biopsies than homozygous carriers of the lower-affinity allele (ptc score >/=1: 
      53.6% vs 25.9%; P = .018). Associations were independent of C1q-binding to DSA or 
      capillary C4d. In parallel, there was a trend toward increased macrophage- and 
      injury-repair response-associated transcript subsets. Kidney function over 
      24 months, however, was not different. In support of a functional role of 
      FcgammaRIIIA polymorphism, NK92 cells expressing FCGR3A-V(158) produced >2 times as 
      much interferon gamma upon incubation with HLA antibody-coated cells as those 
      expressing FCGR3A-F(158) . FcgammaRIIA and FcgammaRIIIB polymorphisms were not associated 
      with allograft morphology. Our data suggest that the presence of high-affinity 
      FcgammaRIIIA variants may favor DSA-triggered microcirculation inflammation.
CI  - (c) 2018 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Arnold, M L
AU  - Arnold ML
AD  - Department of Internal Medicine 3, Institute for Clinical Immunology, 
      Friedrich-Alexander University, Erlangen-Nuremberg, Germany.
FAU - Kainz, A
AU  - Kainz A
AD  - Division of Nephrology and Dialysis, Department of Medicine III, Medical 
      University of Vienna, Vienna, Austria.
FAU - Hidalgo, L G
AU  - Hidalgo LG
AD  - Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Eskandary, F
AU  - Eskandary F
AD  - Division of Nephrology and Dialysis, Department of Medicine III, Medical 
      University of Vienna, Vienna, Austria.
FAU - Kozakowski, N
AU  - Kozakowski N
AD  - Department of Pathology, Medical University of Vienna, Vienna, Austria.
FAU - Wahrmann, M
AU  - Wahrmann M
AD  - Division of Nephrology and Dialysis, Department of Medicine III, Medical 
      University of Vienna, Vienna, Austria.
FAU - Haslacher, H
AU  - Haslacher H
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
FAU - Oberbauer, R
AU  - Oberbauer R
AD  - Division of Nephrology and Dialysis, Department of Medicine III, Medical 
      University of Vienna, Vienna, Austria.
FAU - Heilos, A
AU  - Heilos A
AD  - Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, 
      Vienna, Austria.
FAU - Spriewald, B M
AU  - Spriewald BM
AD  - Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander 
      University, Erlangen-Nuremberg, Germany.
FAU - Halloran, P F
AU  - Halloran PF
AD  - Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, 
      Edmonton, AB, Canada.
FAU - Bohmig, G A
AU  - Bohmig GA
AD  - Division of Nephrology and Dialysis, Department of Medicine III, Medical 
      University of Vienna, Vienna, Austria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180330
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (FCGR2A protein, human)
RN  - 0 (FCGR3A protein, human)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Isoantibodies)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - GPI-Linked Proteins/genetics
MH  - Genotype
MH  - Graft Rejection/*diagnosis/etiology
MH  - Graft Survival
MH  - Humans
MH  - Inflammation/*diagnosis/etiology
MH  - Isoantibodies/*adverse effects
MH  - Kidney Failure, Chronic/genetics/surgery
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Postoperative Complications
MH  - Prognosis
MH  - Receptors, IgG/*genetics
MH  - Risk Factors
MH  - Tissue Donors
OTO - NOTNLM
OT  - alloantibody
OT  - genetics
OT  - histocompatibility
OT  - kidney transplantation/nephrology
OT  - protocol biopsy
OT  - rejection: antibody-mediated (ABMR)
OT  - translational research/science
EDAT- 2018/02/27 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/02/26 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/02/02 00:00 [revised]
PHST- 2018/02/16 00:00 [accepted]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/02/26 06:00 [entrez]
AID - S1600-6135(22)09698-8 [pii]
AID - 10.1111/ajt.14710 [doi]
PST - ppublish
SO  - Am J Transplant. 2018 Sep;18(9):2261-2273. doi: 10.1111/ajt.14710. Epub 2018 Mar 
      30.