PMID- 29478562
OWN - NLM
STAT- MEDLINE
DCOM- 20180809
LR  - 20190204
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 252
DP  - 2018 Jun 30
TI  - Simultaneous determination of clanobutin, dichlorvos, and naftazone in pork, 
      beef, chicken, milk, and egg using liquid chromatography-tandem mass 
      spectrometry.
PG  - 40-48
LID - S0308-8146(18)30094-3 [pii]
LID - 10.1016/j.foodchem.2018.01.085 [doi]
AB  - A chromatographic method involving a single run was validated for the 
      quantification of clanobutin, dichlorvos, and naftazone in products of animal 
      origin. Pork, beef, chicken, milk, and egg samples were extracted with a solution 
      of 0.1% formic acid in acetonitrile, defatted with n-hexane, centrifuged, and 
      filtered prior to analysis using liquid chromatography-tandem mass spectrometry 
      (LC-/MS/MS). The analytes were separated on a C18 column using a solution of 0.1% 
      formic acid and 10 mM ammonium formate (A) and acetonitrile (B) as the mobile 
      phase. A good linearity over 5-50 ng/g concentration range was obtained with 
      coefficients of determination (R(2)) >/= 0.9807. The intra- and interday accuracy 
      (recovery %) calculated from 3 fortification levels (5, 10, and 20 ng/g) were 
      73.2-108.1% and 71.4-109.8%, and the precisions (expressed relative standard 
      deviations (RSDs)) were 0.9-12.9% and 1.8-10.6%, respectively, for the 3 tested 
      analytes in animal originated foods. The limits of quantification (LOQs) ranged 
      between 0.1 and 1 ng/g, thus enabling the quantification of residual levels below 
      the uniform maximum residue limit (MRL) of 0.01 mg/kg set for compounds having no 
      MRL. The designated methodology was successfully applied to monitor various 
      samples collected from Seoul; the tested analytes were not quantified in any of 
      the market samples. Conclusively, the developed method is simple, sensitive, and 
      accurate, and could be used for the detection of pharmaceuticals in various 
      animal food matrices with variable protein and fat contents.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Park, Jin-A
AU  - Park JA
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Abd El-Aty, A M
AU  - Abd El-Aty AM
AD  - Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 
      12211 Giza, Egypt. Electronic address: amabdelaty@konkuk.ac.kr.
FAU - Zheng, Weijia
AU  - Zheng W
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Kim, Seong-Kwan
AU  - Kim SK
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Cho, Sang-Hyun
AU  - Cho SH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Choi, Jeong-Min
AU  - Choi JM
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Hacimuftuo, Ahmet
AU  - Hacimuftuo A
AD  - Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 
      Turkey.
FAU - Jeong, Ji Hoon
AU  - Jeong JH
AD  - Department of Pharmacology, College of Medicine, Chung-Ang University, 221, 
      Heuksuk-dong, Dongjak-gu, Seoul 156-756, Republic of Korea.
FAU - Wang, Jing
AU  - Wang J
AD  - Institute of Quality Standard and Testing Technology for Agro-products, Chinese 
      Academy of Agricultural Sciences, Key Laboratory of Agro-product Quality and 
      Safety, Ministry of Agriculture, Beijing 100081, PR China.
FAU - Shim, Jae-Han
AU  - Shim JH
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic 
      of Korea.
FAU - Shin, Ho-Chul
AU  - Shin HC
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea. Electronic 
      address: hshin@konkuk.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180112
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Naphthoquinones)
RN  - 15B0523P5L (naftazone)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 7U370BPS14 (Dichlorvos)
RN  - W6Y945055S (clanobutin)
SB  - IM
EIN - Food Chem. 2018 Jul 15;254:390. Hacimuftuo, Ahmet [corrected to Hacimuftuoglu, 
      Ahmet]. PMID: 29548468
MH  - Animals
MH  - Cattle
MH  - Chromatography, Liquid/*methods
MH  - Dichlorvos/analysis
MH  - Food Analysis/*methods
MH  - Food Contamination/analysis
MH  - Milk/*chemistry
MH  - Naphthoquinones/analysis
MH  - Ovum/*chemistry
MH  - *Poultry
MH  - Red Meat/*analysis
MH  - Tandem Mass Spectrometry/*methods
MH  - Time Factors
MH  - gamma-Aminobutyric Acid/analogs & derivatives/analysis
OTO - NOTNLM
OT  - Animal-based food products
OT  - Clanobutin
OT  - Determination
OT  - Dichlorvos
OT  - Naftazone
OT  - Residue analysis
OT  - Simultaneous
EDAT- 2018/02/27 06:00
MHDA- 2018/08/10 06:00
CRDT- 2018/02/27 06:00
PHST- 2017/08/22 00:00 [received]
PHST- 2018/01/10 00:00 [revised]
PHST- 2018/01/11 00:00 [accepted]
PHST- 2018/02/27 06:00 [entrez]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2018/08/10 06:00 [medline]
AID - S0308-8146(18)30094-3 [pii]
AID - 10.1016/j.foodchem.2018.01.085 [doi]
PST - ppublish
SO  - Food Chem. 2018 Jun 30;252:40-48. doi: 10.1016/j.foodchem.2018.01.085. Epub 2018 
      Jan 12.