PMID- 29480037
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20210109
IS  - 1751-2441 (Electronic)
IS  - 1751-2433 (Linking)
VI  - 11
IP  - 4
DP  - 2018 Apr
TI  - Pharmacological management of diabetes in severe mental illness: a comprehensive 
      clinical review of efficacy, safety and tolerability.
PG  - 411-424
LID - 10.1080/17512433.2018.1445968 [doi]
AB  - The increased prevalence of Type 2 diabetes mellitus (T2DM) in severe mental 
      illness (SMI) contributes to increased cardiovascular morbidity and reduced life 
      expectancy for people with SMI. Areas covered: In the present clinical review, we 
      summarize the efficacy, safety and tolerability of selected diabetic 
      pharmacotherapy options in SMI and discuss the quality and strength of evidence. 
      Expert commentary: General principles for treating T2DM in SMI involve 
      identifying treatments which promote weight loss and which have low or no risk of 
      hypoglycemia. Patient engagement in decision making about treatment choices is an 
      important factor to ensure adherence and successful use of the chosen therapy. 
      The first line therapeutic option for T2DM in SMI for which there is most 
      evidence is metformin. Based on general population data, second line treatment 
      options in combination with metformin to achieve glycated haemoglobin treatment 
      goals include GLP-1R agonists, DPP-4 inhibitors, sulphonylureas, SGLT2 
      inhibitors, pioglitazone and insulin, with most evidence for the use of GLP-1R 
      agonists in SMI. Alongside efficacy and tolerability, treatment for T2DM in SMI 
      should be considered on a patient-tailored basis.
FAU - Lally, John
AU  - Lally J
AUID- ORCID: 0000-0003-3038-0625
AD  - a Department of Psychosis Studies, Institute of Psychiatry, Psychology & 
      Neuroscience , King's College London , London , UK.
AD  - b Department of Psychiatry, School of Medicine and Medical Sciences , University 
      College Dublin, St Vincent's University Hospital , Dublin , Ireland.
AD  - c Department of Psychiatry , Royal College of Surgeons in Ireland, Beaumont 
      Hospital , Dublin , Ireland.
FAU - O' Loughlin, Aonghus
AU  - O' Loughlin A
AD  - d Department of Medicine , Bon Secours Hospital , Galway , Ireland.
FAU - Stubbs, Brendon
AU  - Stubbs B
AD  - e Psychological Medicine Department, Institute of Psychiatry, Psychology and 
      Neuroscience , King's College London , UK.
AD  - f Physiotherapy Department , South London and Maudsley NHS Foundation Trust , 
      London , UK.
FAU - Guerandel, Allys
AU  - Guerandel A
AD  - b Department of Psychiatry, School of Medicine and Medical Sciences , University 
      College Dublin, St Vincent's University Hospital , Dublin , Ireland.
FAU - O'Shea, Donal
AU  - O'Shea D
AD  - g Education Research Centre , St. Vincent's University Hospital , Dublin , 
      Ireland.
AD  - h Endocrine Unit , St Columcille's Hospital , Loughlinstown , County Dublin , 
      Ireland.
FAU - Gaughran, Fiona
AU  - Gaughran F
AD  - a Department of Psychosis Studies, Institute of Psychiatry, Psychology & 
      Neuroscience , King's College London , London , UK.
AD  - i National Psychosis Service , South London and Maudsley NHS Foundation trust , 
      London , UK.
LA  - eng
GR  - ICA-CL-2017-03-001/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20180309
PL  - England
TA  - Expert Rev Clin Pharmacol
JT  - Expert review of clinical pharmacology
JID - 101278296
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Animals
MH  - Decision Making
MH  - Diabetes Mellitus, Type 2/*drug therapy/epidemiology
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/adverse effects/pharmacology
MH  - Medication Adherence
MH  - Mental Disorders/*physiopathology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Weight Loss/drug effects
OTO - NOTNLM
OT  - GLP-1R agonists
OT  - Schizophrenia
OT  - antipsychotics
OT  - metformin
OT  - psychosis
EDAT- 2018/02/27 06:00
MHDA- 2018/04/06 06:00
CRDT- 2018/02/27 06:00
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2018/04/06 06:00 [medline]
PHST- 2018/02/27 06:00 [entrez]
AID - 10.1080/17512433.2018.1445968 [doi]
PST - ppublish
SO  - Expert Rev Clin Pharmacol. 2018 Apr;11(4):411-424. doi: 
      10.1080/17512433.2018.1445968. Epub 2018 Mar 9.