PMID- 29480080
OWN - NLM
STAT- MEDLINE
DCOM- 20181101
LR  - 20190501
IS  - 1945-5119 (Electronic)
IS  - 1074-9357 (Print)
IS  - 1074-9357 (Linking)
VI  - 25
IP  - 4
DP  - 2018 May
TI  - The relationship between BDNF Val66Met polymorphism and functional mobility in 
      chronic stroke survivors.
PG  - 276-280
LID - 10.1080/10749357.2018.1437938 [doi]
AB  - Background A single nucleotide polymorphism, Val66Met, in the Brain Derived 
      Neurotrophic Factor (BDNF) gene has been studied for its role in recovery 
      following stroke. Despite this work, the role of BDNF genotype on long-term 
      recovery is unclear. Additionally, no study has examined its impact on functional 
      mobility. As a result, the purpose of this study was to examine the relationship 
      between BDNF genotype and functional mobility in chronic stroke survivors by 
      first accounting for factors related to the Val66Met polymorphism and post-stroke 
      recovery. Methods Participants 6 months post-stroke completed the Fugl-Meyer 
      Lower Extremity Assessment (FMLE), Yesavage Geriatric Depression Scale (YGDS), 10 
      meter walk test (SSWS), and BDNF genotype testing. A regression model was used to 
      determine if including genotype (Val or Met) and the genotype's interactions with 
      age, gender, and depression increased the model's fit in predicting functional 
      mobility, as measured by SSWS, after accounting for physical impairment (FMLE) 
      and personal information (age, gender, and YGDS). Results Sixty-three subjects, 
      twenty-two percent of whom had at least one Met allele, were included. Impairment 
      and personal information significantly predicted SSWS (R(2) = 0.268, p < 0.001 
      and DeltaR(2) = 0.158, p = 0.002, respectively). The addition of genotype and 
      genotype's interactions did not significantly increase the variance accounted for 
      in SSWS (DeltaR(2) = 0.012, p = 0.27, and DeltaR(2) = 0.006, p = 0.723, respectively). 
      Conclusions Our results suggest that the Val66Met polymorphism does not predict 
      long-term, functional mobility following stroke. This difference may be due to 
      differences in model variables or a reduced impact of the polymorphism as 
      recovery progresses.
FAU - French, Margaret A
AU  - French MA
AUID- ORCID: 0000-0002-3581-7374
AD  - a Department of Physical Therapy, College of Health Sciences , University of 
      Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program, College of Health Sciences , 
      University of Delaware , Newark , DE , USA.
FAU - Morton, Susanne M
AU  - Morton SM
AD  - a Department of Physical Therapy, College of Health Sciences , University of 
      Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program, College of Health Sciences , 
      University of Delaware , Newark , DE , USA.
FAU - Pohlig, Ryan T
AU  - Pohlig RT
AD  - c Biostatistics Core Facility, College of Health Sciences , University of 
      Delaware , Newark , DE , USA.
FAU - Reisman, Darcy S
AU  - Reisman DS
AD  - a Department of Physical Therapy, College of Health Sciences , University of 
      Delaware , Newark , DE , USA.
AD  - b Biomechanics and Movement Science Program, College of Health Sciences , 
      University of Delaware , Newark , DE , USA.
LA  - eng
GR  - R01 HD078330/HD/NICHD NIH HHS/United States
GR  - R01 HD086362/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180225
PL  - England
TA  - Top Stroke Rehabil
JT  - Topics in stroke rehabilitation
JID - 9439750
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Regression Analysis
MH  - Severity of Illness Index
MH  - Stroke/*genetics/mortality/*physiopathology
MH  - *Survivors
MH  - Valine/genetics
PMC - PMC5901741
MID - NIHMS957773
OTO - NOTNLM
OT  - Stroke
OT  - brain-derived neurotrophic factor
OT  - function
OT  - genotype
OT  - prognosis
OT  - recovery
COIS- Disclosure Statement: The authors report no conflicts of interests.
EDAT- 2018/02/27 06:00
MHDA- 2018/11/02 06:00
PMCR- 2019/05/01
CRDT- 2018/02/27 06:00
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2018/11/02 06:00 [medline]
PHST- 2018/02/27 06:00 [entrez]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 10.1080/10749357.2018.1437938 [doi]
PST - ppublish
SO  - Top Stroke Rehabil. 2018 May;25(4):276-280. doi: 10.1080/10749357.2018.1437938. 
      Epub 2018 Feb 25.