PMID- 29480583
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 24
IP  - 3
DP  - 2019 May
TI  - Stress augments the rewarding memory of cocaine via the activation of 
      brainstem-reward circuitry.
PG  - 509-521
LID - 10.1111/adb.12617 [doi]
AB  - Effects of stress on the reward system are well established in the literature. 
      Although previous studies have revealed that stress can reinstate extinguished 
      addictive behaviors related to cocaine, the effects of stress on the rewarding 
      memory of cocaine are not fully understood. Here, we provide evidence that stress 
      potentiates the expression of rewarding memory of cocaine via the activation of 
      brainstem-reward circuitry using a cocaine-induced conditioned place preference 
      (CPP) paradigm combined with restraint stress in rats. The rats exposed to 
      30-minute restraint stress immediately before posttest exhibited significantly 
      larger CPP scores compared with non-stressed rats. Intra-laterodorsal tegmental 
      nucleus (LDT) microinjection of a beta or alpha2 adrenoceptor antagonist attenuated the 
      stress-induced enhancement of cocaine CPP. Consistent with this observation, 
      intra-LDT microinjection of a beta or alpha2 adrenoceptor agonist before posttest 
      increased cocaine CPP. Additionally, intra-ventral tegmental area (VTA) 
      microinjection of antagonists for the muscarinic acetylcholine, nicotinic 
      acetylcholine or glutamate receptors attenuated the stress-induced enhancement of 
      cocaine CPP. Finally, intra-medial prefrontal cortex (mPFC) microinjection of a 
      D1 receptor antagonist also reduced the stress-induced enhancement of cocaine 
      CPP. These findings suggest a mechanism wherein the LDT is activated by 
      noradrenergic input from the locus coeruleus, leading to the activation of VTA 
      dopamine neurons via both cholinergic and glutamatergic transmission and the 
      subsequent excitation of the mPFC to enhance the memory of cocaine-induced reward 
      value.
CI  - (c) 2018 Society for the Study of Addiction.
FAU - Shinohara, Fumiya
AU  - Shinohara F
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido 
      University, Sapporo, Japan.
FAU - Asaoka, Yuta
AU  - Asaoka Y
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido 
      University, Sapporo, Japan.
FAU - Kamii, Hironori
AU  - Kamii H
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido 
      University, Sapporo, Japan.
AD  - Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and 
      Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Minami, Masabumi
AU  - Minami M
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido 
      University, Sapporo, Japan.
FAU - Kaneda, Katsuyuki
AU  - Kaneda K
AUID- ORCID: 0000-0001-7046-9275
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido 
      University, Sapporo, Japan.
AD  - Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and 
      Health Sciences, Kanazawa University, Kanazawa, Japan.
LA  - eng
GR  - The Natio Foundation/International
GR  - Hoansha Foundation/International
GR  - 15K06765/Grant-in-Aid for Scientific Research (C)/International
GR  - 26120702/Grant-in-Aid for Scientific Research on Innovative Areas/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180226
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, Adrenergic, alpha-2)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 817W3C6175 (Timolol)
RN  - E27LB7P0ET (2-methoxyidazoxan)
RN  - I5Y540LHVR (Cocaine)
RN  - Y310PA316B (Idazoxan)
SB  - IM
MH  - Adrenergic Neurons/drug effects
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Animals
MH  - Brain Stem/drug effects
MH  - Cocaine/*pharmacology
MH  - Conditioning, Psychological/drug effects
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Idazoxan/analogs & derivatives/pharmacology
MH  - Male
MH  - Memory/*drug effects
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adrenergic, alpha-2/physiology
MH  - Receptors, Adrenergic, beta/physiology
MH  - Restraint, Physical
MH  - *Reward
MH  - Stress, Psychological/physiopathology
MH  - Tegmentum Mesencephali/drug effects
MH  - Timolol/pharmacology
OTO - NOTNLM
OT  - addiction
OT  - dopamine
OT  - laterodorsal tegmental nucleus
OT  - medial prefrontal cortex
OT  - noradrenaline
OT  - ventral tegmental area
EDAT- 2018/02/27 06:00
MHDA- 2020/05/19 06:00
CRDT- 2018/02/27 06:00
PHST- 2017/08/18 00:00 [received]
PHST- 2018/01/09 00:00 [revised]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/02/27 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2018/02/27 06:00 [entrez]
AID - 10.1111/adb.12617 [doi]
PST - ppublish
SO  - Addict Biol. 2019 May;24(3):509-521. doi: 10.1111/adb.12617. Epub 2018 Feb 26.