PMID- 29483385
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20220316
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 131
IP  - 5
DP  - 2018 Mar 5
TI  - Comparison of Clinical Effects between Percutaneous Transluminal Septal 
      Myocardial Ablation and Modified Morrow Septal Myectomy on Patients with 
      Hypertrophic Cardiomyopathy.
PG  - 527-531
LID - 10.4103/0366-6999.226075 [doi]
AB  - BACKGROUND: Percutaneous transluminal septal myocardial ablation (PTSMA) and 
      modified Morrow septal myectomy (MMSM) are two invasive strategies used to 
      relieve obstruction in patients with hypertrophic cardiomyopathy (HCM). This 
      study aimed to determine the clinical outcome of these two strategies. METHODS: 
      From January 2011 to January 2015, 226 patients with HCM were treated, 68 by 
      PTSMA and 158 by MMSM. Both ultrasonic cardiograms and heart functional class 
      were recorded before, after operations and in the follow-up. Categorical 
      variables were compared using Chi-square or Fisher's exact tests. Quantitative 
      variables were compared using the paired samples t-test. RESULTS: 
      Interventricular septal thickness was significantly reduced in both groups (21.27 
      +/- 4.43 mm vs. 18.72 +/- 4.13 mm for PTSMA, t = 3.469, P < 0.001, and 21.83 +/- 5.03 
      mm vs. 16.57 +/- 3.95 mm for MMSM, t = 10.349, P < 0.001, respectively). The left 
      ventricular outflow tract (LVOT) pressure gradient (PG) significantly decreased 
      after the operations in two groups (70.30 +/- 44.79 mmHg vs. 39.78 +/- 22.07 mmHg for 
      PTSMA, t = 5.041, P < 0.001, and 74.58 +/- 45.52 mmHg vs. 13.95 +/- 9.94 mmHg for 
      MMSM, t = 16.357, P < 0.001, respectively). Seven patients (10.29%) in the PTSMA 
      group required a repeat operation in the follow-up. Eight (11.76%) patients were 
      evaluated for New York Heart Association (NYHA) III/IV in the PTSMA group, which 
      was significantly more than the five (3.16%) in the same NYHA classes for the 
      MMSM group at follow-up. Less than 15% of patients in the PTSMA group and none of 
      the patients in the MMSM group complained of chest pain during follow-up. 
      CONCLUSIONS: Both strategies can not only relieve LVOT PG but also improve heart 
      function in patients with HCM. However, MMSM might provide a more reliable 
      reduction in gradients compared to PTSMA.
FAU - Guo, Hong-Chang
AU  - Guo HC
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
FAU - Li, Jin-Hua
AU  - Li JH
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
FAU - Jiang, Teng-Yong
AU  - Jiang TY
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, China.
FAU - Ren, Chang-Wei
AU  - Ren CW
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
FAU - Dai, Jiang
AU  - Dai J
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
FAU - Zhou, Yu-Jie
AU  - Zhou YJ
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, China.
FAU - Lai, Yong-Qiang
AU  - Lai YQ
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adult
MH  - Cardiac Surgical Procedures/*methods
MH  - Cardiomyopathy, Hypertrophic/diagnostic imaging/*surgery
MH  - Catheter Ablation/methods
MH  - Echocardiography
MH  - Female
MH  - Heart Septum/diagnostic imaging/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
PMC - PMC5850667
OTO - NOTNLM
OT  - Hypertrophic Cardiomyopathy
OT  - Myectomy
OT  - Percutaneous Transluminal Septal Myocardial Ablation
COIS- There are no conflicts of interest.
EDAT- 2018/02/28 06:00
MHDA- 2018/09/05 06:00
PMCR- 2018/03/05
CRDT- 2018/02/28 06:00
PHST- 2018/02/28 06:00 [entrez]
PHST- 2018/02/28 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/03/05 00:00 [pmc-release]
AID - ChinMedJ_2018_131_5_527_226075 [pii]
AID - CMJ-131-527 [pii]
AID - 10.4103/0366-6999.226075 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2018 Mar 5;131(5):527-531. doi: 10.4103/0366-6999.226075.