PMID- 29483614
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20221207
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 20
IP  - 1
DP  - 2019 Jan
TI  - HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women.
PG  - 69-73
LID - 10.1038/s41435-018-0014-3 [doi]
AB  - Associations between human leukocyte antigen (HLA) variants and chlamydia-related 
      outcomes have been inconsistent. We previously identified HLA-DQB1*06 as a risk 
      marker for chlamydia reinfection in a cohort of predominately HIV-infected 
      adolescents. As chlamydia reinfection can lead to reproductive complications, 
      validation of this finding in HIV-seronegative women may help reveal the 
      underlying biology. We performed HLA-DQB1 genotyping in HIV-seronegative, 
      chlamydia-infected African American women who were evaluated for reinfection at 
      3- and 6-month visits after treatment. Of 185 evaluable women for whom HLA-DQB1 
      genotyping was performed, only HLA-DQB1*06 was associated with chlamydia 
      reinfection (P = 0.009), with no evidence of a dose-response effect for this 
      allele. African American women with HLA-DQB1*06 may warrant more frequent 
      chlamydia screening. More comprehensive genotyping of HLA class II and 
      neighboring genes is needed to establish whether HLA-DQB1*06 is a causal variant 
      for chlamydia reinfection or a surrogate for other causal variants in the major 
      histocompatibility complex.
FAU - Olson, Kristin M
AU  - Olson KM
AUID- ORCID: 0000-0002-2146-7705
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Tang, Jianming
AU  - Tang J
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Brown, LaDraka'
AU  - Brown L
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Press, Christen G
AU  - Press CG
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Geisler, William M
AU  - Geisler WM
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 
      wgeisler@uabmc.edu.
LA  - eng
GR  - UL1 TR003096/TR/NCATS NIH HHS/United States
GR  - TL1 TR001418/TR/NCATS NIH HHS/United States
GR  - K24 AI125685/AI/NIAID NIH HHS/United States
GR  - UL1 TR001417/TR/NCATS NIH HHS/United States
GR  - T32 GM008361/GM/NIGMS NIH HHS/United States
GR  - R01 AI093692/AI/NIAID NIH HHS/United States
GR  - F31 HD094539/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180226
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American
MH  - Chlamydia Infections/*genetics
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
PMC - PMC6109624
MID - NIHMS937764
COIS- CONFLICT OF INTEREST The authors declare no conflicts of interest.
EDAT- 2018/02/28 06:00
MHDA- 2019/04/02 06:00
PMCR- 2018/08/28
CRDT- 2018/02/28 06:00
PHST- 2017/11/08 00:00 [received]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/01/19 00:00 [revised]
PHST- 2018/02/28 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/02/28 06:00 [entrez]
PHST- 2018/08/28 00:00 [pmc-release]
AID - 10.1038/s41435-018-0014-3 [pii]
AID - 10.1038/s41435-018-0014-3 [doi]
PST - ppublish
SO  - Genes Immun. 2019 Jan;20(1):69-73. doi: 10.1038/s41435-018-0014-3. Epub 2018 Feb 
      26.