PMID- 29483674
OWN - NLM
STAT- MEDLINE
DCOM- 20190923
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Feb 26
TI  - Prediabetes and diabetes in a cohort of Qatari women screened for polycystic 
      ovary syndrome.
PG  - 3619
LID - 10.1038/s41598-018-21987-6 [doi]
LID - 3619
AB  - Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 
      diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown 
      in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar 
      Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the 
      National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 
      5.7-6.4% and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 
      100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL 
      (>/=7 mmol/L), and/or HbA1c >/= 6.5%) were determined. The prevalence of prediabetes 
      was 10.6% and the prevalence of undiagnosed diabetes was found to be 4.0% in the 
      total population. Overall, 12.1% of 720 women had PCOS, of whom FPG and HbA1c 
      were available in 62 women with PCOS: 19.4% had prediabetes and 9.7% had 
      diabetes. An adverse cardiovascular risk profile for IFG women compared to normal 
      women was found. Women with PCOS alone had a similar adverse cardiovascular 
      profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and 
      diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular 
      risk profile similar to that seen in prediabetes and T2DM.
FAU - Dargham, Soha R
AU  - Dargham SR
AD  - Infectious Disease Epidemiology Group, Weill Cornell Medicine, Doha, PO Box 
      24144, Qatar.
FAU - Shewehy, Abeer El
AU  - Shewehy AE
AUID- ORCID: 0000-0002-9289-6654
AD  - Research Faculty, Weill Cornell Medicine, Doha, PO Box 24144, Qatar.
FAU - Dakroury, Youssra
AU  - Dakroury Y
AUID- ORCID: 0000-0002-2839-6831
AD  - Research Faculty, Weill Cornell Medicine, Doha, PO Box 24144, Qatar.
FAU - Kilpatrick, Eric S
AU  - Kilpatrick ES
AD  - Department of Pathology, Sidra Medical and Research Center, Doha, PO Box 26999, 
      Qatar.
FAU - Atkin, Stephen L
AU  - Atkin SL
AUID- ORCID: 0000-0002-5887-7257
AD  - Research Faculty, Weill Cornell Medicine, Doha, PO Box 24144, Qatar. 
      sla2002@qatar-med.cornell.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180226
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis
MH  - Fasting/blood
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Polycystic Ovary Syndrome/blood/*diagnosis
MH  - Prediabetic State/blood/*diagnosis
MH  - Waist Circumference
MH  - Young Adult
PMC - PMC5827735
COIS- The authors declare no competing interests.
EDAT- 2018/02/28 06:00
MHDA- 2019/09/24 06:00
PMCR- 2018/02/26
CRDT- 2018/02/28 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2018/02/14 00:00 [accepted]
PHST- 2018/02/28 06:00 [entrez]
PHST- 2018/02/28 06:00 [pubmed]
PHST- 2019/09/24 06:00 [medline]
PHST- 2018/02/26 00:00 [pmc-release]
AID - 10.1038/s41598-018-21987-6 [pii]
AID - 21987 [pii]
AID - 10.1038/s41598-018-21987-6 [doi]
PST - epublish
SO  - Sci Rep. 2018 Feb 26;8(1):3619. doi: 10.1038/s41598-018-21987-6.