PMID- 29484302
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20240315
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2018
DP  - 2018
TI  - The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes 
      Mellitus Patients in Ghana.
PG  - 4783093
LID - 10.1155/2018/4783093 [doi]
LID - 4783093
AB  - BACKGROUND: Thyroid dysfunction is known to exaggerate the coronary heart disease 
      (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The 
      effect is yet to be studied among African populations. METHODS: This is a 
      cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic 
      in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk 
      scores. Risks were categorised as low (<10%), intermediate (10-19%), and high 
      (>/=20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD 
      risk were measured using Spearman's partial correlation analysis while 
      controlling for age and gender. Differences were considered statistically 
      significant at p < 0.05. RESULTS: 780 T2DM patients (57.7% females), mean +/- SD 
      age of 57.4 +/- 9.4 was analysed. The median (IQR) 10-year CHD score estimated 
      using the Framingham and UKPDS risk engines for males and females was 12 (8-20), 
      9.4 (5.7-13.4), p < 0.0001 and 3 (1-6), 5.8 (3.4-9.6), p < 0.0001, respectively. 
      Positive correlation was found between CHD risk and HbA1c, total cholesterol, 
      low-density lipoprotein cholesterol, systolic blood pressure, and thyroid 
      stimulating hormone. CONCLUSION: The presence of thyroid dysfunction 
      significantly increased the CHD risk associated with T2DM patients in Ghana.
FAU - Sarfo-Kantanka, Osei
AU  - Sarfo-Kantanka O
AUID- ORCID: 0000-0002-4451-5749
AD  - Komfo Anokye Teaching Hospital, Kumasi, Ghana.
FAU - Sarfo, Fred Stephen
AU  - Sarfo FS
AD  - Komfo Anokye Teaching Hospital, Kumasi, Ghana.
AD  - Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
FAU - Ansah, Eunice Oparebea
AU  - Ansah EO
AD  - Komfo Anokye Teaching Hospital, Kumasi, Ghana.
FAU - Kyei, Ishmael
AU  - Kyei I
AD  - Komfo Anokye Teaching Hospital, Kumasi, Ghana.
LA  - eng
PT  - Journal Article
DEP - 20180201
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Cardiovascular Diseases/*epidemiology/metabolism/physiopathology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology/metabolism/physiopathology
MH  - Female
MH  - Ghana/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Thyroid Diseases/complications/*epidemiology/metabolism/physiopathology
PMC - PMC5816870
EDAT- 2018/02/28 06:00
MHDA- 2018/09/25 06:00
PMCR- 2018/02/01
CRDT- 2018/02/28 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/10/14 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2018/02/28 06:00 [entrez]
PHST- 2018/02/28 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1155/2018/4783093 [doi]
PST - epublish
SO  - J Diabetes Res. 2018 Feb 1;2018:4783093. doi: 10.1155/2018/4783093. eCollection 
      2018.