PMID- 29485799
OWN - NLM
STAT- MEDLINE
DCOM- 20190124
LR  - 20190124
IS  - 0353-9466 (Print)
IS  - 0353-9466 (Linking)
VI  - 56
IP  - 2
DP  - 2017 Jun
TI  - Development of Respiratory Allergies, Asthma and Allergic Rhinits in Children 
      with Atopic Dermatitis.
PG  - 308-317
LID - 10.20471/acc.2017.56.02.15 [doi]
AB  - Children with atopic dermatitis (AD) usually develop symptoms when they reach the 
      age of 6-7 years, but the risk of developing respiratory allergies, asthma and 
      allergic rhinitis (AR) remains high. In most children with AD, the development of 
      asthma and AR is associated with sensitization to food allergens and/or 
      aeroallergens, while only a small percentage missed atopic diathesis. In about 
      35% of children with AD, food allergy is the provoking cause, and 60% of infants 
      who had AD in the first 3 months of life were sensitized against aeroallergens by 
      the age of 5. The aim of the study was to follow development of asthma and AR and 
      to assess the most significant risk factors for developing respiratory allergy. A 
      total of 114 children with AD were followed up for five years. At annual visits, 
      the severity of disease, total immunoglobulin E (IgE) antibody values, skin prick 
      tests, specific IgE antibodies to food allergens and aeroallergens, and absolute 
      eosinophil count were assessed. Information on the family history of atopy and 
      AD, feeding patterns during infancy, data on sensitivity to food allergens and/or 
      aeroallergens, and on the occurrence of bronchial obstruction and nose symptoms 
      were obtained. Asthma developed in 36 children, median age 7.7 years; 33 children 
      had symptoms of AR, and 13 children with AD had both diseases associated; 38 
      children had sensitivity to food, of which 24 developed asthma and 13 AR; asthma 
      developed in 18/23 children with sensitivity to aeroallergens, and almost an 
      equal number of children developed AR. The increased absolute eosinophil count 
      and specific IgE to aeroallergens and food allergens were the best asthma 
      predictors, while AR predictors were family history and early onset of AD. In 
      conclusion, children with AD are at a significant risk of developing respiratory 
      allergies, and those with the increased absolute eosinophil count, positive 
      specific IgE to aeroallergens and food allergens, heredity of AD, and early onset 
      of AD are at the highest risk. Identification of risk factors will enable us to 
      improve the treatments of AD in order to reduce the severity of disease and 
      prevent manifestation of respiratory allergy.
FAU - Cosickic, Almira
AU  - Cosickic A
AD  - Clinical Department for Children's Diseases, Tuzla University Clinical Center.
FAU - Skokic, Fahrija
AU  - Skokic F
AD  - Clinical Department for Children's Diseases, Tuzla University Clinical Center.
FAU - Selimovic, Amela
AU  - Selimovic A
AD  - Clinical Department for Children's Diseases, Tuzla University Clinical Center.
FAU - Mulic, Maida
AU  - Mulic M
AD  - Public Health Institute of Tuzla Canton.
FAU - Suljendic, Sanimir
AU  - Suljendic S
AD  - Clinical Department for Children's Diseases, Tuzla University Clinical Center.
FAU - Dedic, Nermina
AU  - Dedic N
AD  - Clinical Department for Children's Diseases, Tuzla University Clinical Center.
FAU - Sabitovic, Damir
AU  - Sabitovic D
AD  - Polyclinic for Laboratory Diagnosis, Tuzla University Clinical Center, Tuzla, 
      Bosnia and Herzegovina.
FAU - Dzafic, Fejzo
AU  - Dzafic F
AD  - Polyclinic for Laboratory Diagnosis, Tuzla University Clinical Center, Tuzla, 
      Bosnia and Herzegovina.
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Acta Clin Croat
JT  - Acta clinica Croatica
JID - 9425483
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Asthma/complications/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Dermatitis, Atopic/*complications/immunology
MH  - Eosinophils/immunology
MH  - Female
MH  - Food Hypersensitivity/complications/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Prospective Studies
MH  - Respiratory Hypersensitivity/*complications/immunology
MH  - Rhinitis, Allergic/complications/immunology
MH  - Risk Factors
MH  - Skin Tests
OTO - NOTNLM
OT  - Asthma
OT  - Child, preschool
OT  - Dermatitis, atopic
OT  - Rhinitis, allergic
EDAT- 2018/02/28 06:00
MHDA- 2019/01/25 06:00
CRDT- 2018/02/28 06:00
PHST- 2018/02/28 06:00 [entrez]
PHST- 2018/02/28 06:00 [pubmed]
PHST- 2019/01/25 06:00 [medline]
AID - 10.20471/acc.2017.56.02.15 [doi]
PST - ppublish
SO  - Acta Clin Croat. 2017 Jun;56(2):308-317. doi: 10.20471/acc.2017.56.02.15.