PMID- 29486579
OWN - NLM
STAT- MEDLINE
DCOM- 20191002
LR  - 20191002
IS  - 1938-2707 (Electronic)
IS  - 0009-9228 (Linking)
VI  - 57
IP  - 10
DP  - 2018 Sep
TI  - Vital Signs as Predictor Factors of Intravenous Immunoglobulin Resistance in 
      Patients With Kawasaki Disease.
PG  - 1148-1153
LID - 10.1177/0009922818759320 [doi]
AB  - Kawasaki disease (KD) is the most common cause of acquired heart disease in 
      children. Intravenous immunoglobulin (IVIG) may significantly lower the frequency 
      of coronary artery complications. However, some patients do not respond to 
      initial therapy and are at higher risk of developing coronary artery lesion. A 
      retrospective analysis of data from 419 KD patients was performed. The patients 
      were divided into IVIG responders (n = 318) and IVIG nonresponders (n = 101). 
      Multivariate logistic regression analysis revealed neutrophil percentage, 
      albumin, aspartate aminotransferase, heart rate, and body temperature were 
      independent predictors of IVIG resistance. We generated a predictive scoring 
      system by assigning 1 point for the presence of these parameters (neutrophil 
      >80%, albumin <3.4 g/dL, aspartate aminotransferase >100 IU/L, heart rate >146 
      bpm, and body temperature >38.8 degrees C). This scoring system had a sensitivity of 
      76.2% and specificity of 64.8%, and a positive predictive value of 40.1% and a 
      negative predictive value of 89.4%. Vital signs may be helpful to detect KD 
      patients with IVIG resistance.
FAU - Gamez-Gonzalez, Luisa Berenise
AU  - Gamez-Gonzalez LB
AD  - 1 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Chiba, Japan.
AD  - 2 Department of Allergy and Clinical Immunology, Children's Hospital Chihuahua 
      City, Mexico.
FAU - Hamada, Hiromichi
AU  - Hamada H
AD  - 1 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Chiba, Japan.
FAU - Cisneros Castolo, Martin
AU  - Cisneros Castolo M
AD  - 3 Research Methodology Department, Children's Hospital Chihuahua City, Mexico.
FAU - Honda, Takafumi
AU  - Honda T
AD  - 1 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Chiba, Japan.
FAU - Yasukawa, Kumi
AU  - Yasukawa K
AD  - 1 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Chiba, Japan.
FAU - Takanashi, Jun-Ichi
AU  - Takanashi JI
AUID- ORCID: 0000-0002-1147-1938
AD  - 1 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180227
PL  - United States
TA  - Clin Pediatr (Phila)
JT  - Clinical pediatrics
JID - 0372606
RN  - 0 (Albumins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
SB  - IM
MH  - Albumins/drug effects
MH  - Aspartate Aminotransferases/blood/drug effects
MH  - Body Temperature/drug effects
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Immunoglobulins, Intravenous/blood/*therapeutic use
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/blood/*drug therapy
MH  - Neutrophils/drug effects
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Tokyo
MH  - Treatment Failure
MH  - Vital Signs/*drug effects
OTO - NOTNLM
OT  - Kawasaki disease
OT  - immunoglobulin resistance
OT  - risk score
OT  - vital signs
EDAT- 2018/03/01 06:00
MHDA- 2019/10/03 06:00
CRDT- 2018/03/01 06:00
PHST- 2018/03/01 06:00 [pubmed]
PHST- 2019/10/03 06:00 [medline]
PHST- 2018/03/01 06:00 [entrez]
AID - 10.1177/0009922818759320 [doi]
PST - ppublish
SO  - Clin Pediatr (Phila). 2018 Sep;57(10):1148-1153. doi: 10.1177/0009922818759320. 
      Epub 2018 Feb 27.