PMID- 29487347
OWN - NLM
STAT- MEDLINE
DCOM- 20190923
LR  - 20240315
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Feb 27
TI  - Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut 
      microbiota.
PG  - 3685
LID - 10.1038/s41598-018-22094-2 [doi]
LID - 3685
AB  - Type 2 diabetes mellitus (T2DM), a chronic metabolic disease which severely 
      impairs peoples' quality of life, currently attracted worldwide concerns. There 
      are growing evidences that gut microbiota can exert a great impact on the 
      development of T2DM. Xiexin Tang (XXT), a traditional Chinese medicine 
      prescription, has been clinically used to treat diabetes for thousands of years. 
      However, few researches are investigated on the modulation of gut microbiota 
      community by XXT which will be very helpful to unravel how it works. In this 
      study, bacterial communities were analyzed based on high-throughput 16S rRNA gene 
      sequencing. Results indicated that XXT could notably shape the gut microbiota. 
      T2DM rats treated with XXT exhibited obvious changes in the composition of the 
      gut microbiota, especially for some short chain fatty acids producing and 
      anti-inflammatory bacteria such as Adlercreutzia, Alloprevotella, Barnesiella, 
      [Eubacterium] Ventriosum group, Blautia, Lachnospiraceae UCG-001, Papillibacter 
      and Prevotellaceae NK3B31 group. Additionally, XXT could also significantly 
      ameliorate hyperglycemia, lipid metabolism dysfunction and inflammation in T2DM 
      rats. Moreover, the correlation analysis illustrated that the key microbiota had 
      a close relationship with the T2DM related indexes. The results probably provided 
      useful information for further investigation on its active mechanism and clinical 
      application.
FAU - Wei, Xiaoyan
AU  - Wei X
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Tao, Jinhua
AU  - Tao J
AUID- ORCID: 0000-0002-7221-3107
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Xiao, Suwei
AU  - Xiao S
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Jiang, Shu
AU  - Jiang S
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China. jiangshu2020@126.com.
FAU - Shang, Erxin
AU  - Shang E
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Zhu, Zhenhua
AU  - Zhu Z
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Qian, Dawei
AU  - Qian D
AUID- ORCID: 0000-0002-0402-9551
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China.
FAU - Duan, Jinao
AU  - Duan J
AUID- ORCID: 0000-0002-2066-327X
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing, 210023, PR China. dja@njutcm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180227
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*drug therapy/*microbiology
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Fatty Acids/metabolism
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC5829262
COIS- The authors declare no competing interests.
EDAT- 2018/03/01 06:00
MHDA- 2019/09/24 06:00
PMCR- 2018/02/27
CRDT- 2018/03/01 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/03/01 06:00 [entrez]
PHST- 2018/03/01 06:00 [pubmed]
PHST- 2019/09/24 06:00 [medline]
PHST- 2018/02/27 00:00 [pmc-release]
AID - 10.1038/s41598-018-22094-2 [pii]
AID - 22094 [pii]
AID - 10.1038/s41598-018-22094-2 [doi]
PST - epublish
SO  - Sci Rep. 2018 Feb 27;8(1):3685. doi: 10.1038/s41598-018-22094-2.