PMID- 2948818
OWN - NLM
STAT- MEDLINE
DCOM- 19870326
LR  - 20181130
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 120
IP  - 3
DP  - 1987 Mar
TI  - Adrenergic regulation of beta-endorphin secretion from anterior pituitary in 
      conscious rats: effects of thyroid state.
PG  - 1073-8
AB  - In conscious, chronically cannulated, unrestrained rats, systemic administration 
      of catecholamines increases the plasma levels of beta-endorphin-like 
      immunoreactivity (beta Ei). In euthyroid rats, this effect is mediated by both 
      alpha 1 and beta-adrenergic receptors; the rise in plasma beta Ei caused by 
      isoproterenol is blocked by 1 mg/kg propranolol, and the similar effects of 
      norepinephrine and phenylephrine are blocked by 0.1 mg/kg prazosin. Both types of 
      responses are completely suppressed by a 4-h pretreatment of rats with 0.1 mg/kg 
      dexamethasone, indicating the anterior pituitary origin of the beta Ei released. 
      Prior sectioning of the pituitary stalk does not significantly reduce the 
      response to either phenylephrine or isoproterenol, suggesting that both agents 
      act directly on the pituitary. Hypothyroidism induced by surgical thyroidectomy 
      does not influence the beta Ei response to isoproterenol, which remains sensitive 
      to block by propranolol or suppression by dexamethasone. However, neither 
      norepinephrine nor phenylephrine is able to increase plasma beta Ei in the 
      hypothyroid animals. Both isoproterenol and phenylephrine remain fully effective 
      in rats made hyperthyroid by daily injections of 40 micrograms/kg T3 for 4 days. 
      We propose that in unstressed rats catecholamines increase plasma beta Ei by a 
      direct action on the anterior pituitary via either alpha 1- or beta-adrenergic 
      receptors, and that expression of the alpha 1-, but not the beta-adrenergic 
      response is regulated by thyroid hormones.
FAU - Ishac, E J
AU  - Ishac EJ
FAU - Eskay, R
AU  - Eskay R
FAU - Hirata, F
AU  - Hirata F
FAU - Axelrod, J
AU  - Axelrod J
FAU - Kunos, G
AU  - Kunos G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Endorphins)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - L628TT009W (Isoproterenol)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Animals
MH  - Dexamethasone/pharmacology
MH  - Endorphins/blood/*metabolism
MH  - Isoproterenol/*pharmacology
MH  - Male
MH  - Norepinephrine/*pharmacology
MH  - Phenylephrine/*pharmacology
MH  - Pituitary Gland, Anterior/drug effects/*metabolism
MH  - Prazosin/*pharmacology
MH  - Propranolol/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyroid Gland/*physiology
MH  - *Thyroidectomy
MH  - beta-Endorphin
EDAT- 1987/03/01 00:00
MHDA- 1987/03/01 00:01
CRDT- 1987/03/01 00:00
PHST- 1987/03/01 00:00 [pubmed]
PHST- 1987/03/01 00:01 [medline]
PHST- 1987/03/01 00:00 [entrez]
AID - 10.1210/endo-120-3-1073 [doi]
PST - ppublish
SO  - Endocrinology. 1987 Mar;120(3):1073-8. doi: 10.1210/endo-120-3-1073.