PMID- 29488661
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20180910
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 79
IP  - 4
DP  - 2018 Apr
TI  - The pregnancy hormone human chorionic gonadotropin differentially regulates 
      plasmacytoid and myeloid blood dendritic cell subsets.
PG  - e12837
LID - 10.1111/aji.12837 [doi]
AB  - PROBLEM: Dendritic cells (DCs) are critically involved in fetal fate due to their 
      capability to promote either immunity or tolerance to foreign fetal antigens. Our 
      study aimed to investigate whether the hormone human chorionic gonadotropin (hCG) 
      affects different peripheral blood DC (PBDCs) subsets. METHOD OF STUDY: PBDCs 
      were isolated from non-pregnant women, stimulated and co-cultured with 
      hCG-producing JEG-3 or non hCG-producing SWAN-71 trophoblasts as well as with two 
      different hCG preparations. The total and mature number of each PBDC subset were 
      assessed. Additionally, the secretion of cytokines was determined in the presence 
      or absence of hCG. RESULTS: We found no significant effects; neither from 
      trophoblasts nor from the hCG preparations on PBDC cellularity. JEG-3 cells and 
      both hCG preparations significantly hampered the maturation of MDC1, while 
      SWAN-71 cells did not provoke any changes on this regard. We observed an altered 
      ability of PBDCs to secrete cytokines in the presence of both trophoblasts and 
      both hCG preparations. CONCLUSION: Our data propose that hCG is not a key 
      regulator of cellular alterations within PBDCs. However, under inflammatory 
      conditions, hCG seems to keep the delicate balance between PDC and MDC and 
      retains a tolerogenic MDC1 profile and this may contribute to tolerance 
      maintenance.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Sauss, Karoline
AU  - Sauss K
AD  - Department of Experimental Obstetrics and Gynecology, Medical Faculty, 
      Otto-von-Guericke University, Magdeburg, Germany.
FAU - Ehrentraut, Stefanie
AU  - Ehrentraut S
AD  - Department of Experimental Obstetrics and Gynecology, Medical Faculty, 
      Otto-von-Guericke University, Magdeburg, Germany.
FAU - Zenclussen, Ana Claudia
AU  - Zenclussen AC
AD  - Department of Experimental Obstetrics and Gynecology, Medical Faculty, 
      Otto-von-Guericke University, Magdeburg, Germany.
FAU - Schumacher, Anne
AU  - Schumacher A
AUID- ORCID: 0000-0002-6427-3724
AD  - Department of Experimental Obstetrics and Gynecology, Medical Faculty, 
      Otto-von-Guericke University, Magdeburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180228
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Blood Cells/*immunology
MH  - Cell Differentiation
MH  - Cell Line
MH  - Chorionic Gonadotropin/*metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Myeloid Cells/*immunology
MH  - Pregnancy
MH  - Th1 Cells/immunology
MH  - Trophoblasts/*immunology
MH  - Young Adult
OTO - NOTNLM
OT  - fetal tolerance
OT  - human chorionic gonadotropin
OT  - myeloid dendritic cells
OT  - plasmacytoid dendritic cells
OT  - pregnancy
EDAT- 2018/03/01 06:00
MHDA- 2018/09/11 06:00
CRDT- 2018/03/01 06:00
PHST- 2017/12/06 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/03/01 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/03/01 06:00 [entrez]
AID - 10.1111/aji.12837 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2018 Apr;79(4):e12837. doi: 10.1111/aji.12837. Epub 2018 Feb 
      28.